Feasibility and diagnostic performance of sentinel node biopsy for staging cN0 oral squamous cell carcinoma in a previously treated neck
Abstract Objectives Staging of the cN0 neck with sentinel node biopsy (SNB) in early‐stage oral squamous cell carcinoma (OSCC) is validated in patients with a previously untreated neck. We aimed to investigate the feasibility and diagnostic accuracy of SNB and unexpected drainage patterns in patient...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
|
| Series: | World Journal of Otorhinolaryngology-Head and Neck Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/wjo2.157 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850247470505787392 |
|---|---|
| author | Therese Mørch Jesper F. Tvedskov Irene Wessel Birgitte W. Charabi Kathrine K. Jakobsen Christian Grønhøj Katalin Kiss Giedrius Lelkaitis Jann Mortensen Andreas Kjaer Christian vonBuchwald Anders Christensen |
| author_facet | Therese Mørch Jesper F. Tvedskov Irene Wessel Birgitte W. Charabi Kathrine K. Jakobsen Christian Grønhøj Katalin Kiss Giedrius Lelkaitis Jann Mortensen Andreas Kjaer Christian vonBuchwald Anders Christensen |
| author_sort | Therese Mørch |
| collection | DOAJ |
| description | Abstract Objectives Staging of the cN0 neck with sentinel node biopsy (SNB) in early‐stage oral squamous cell carcinoma (OSCC) is validated in patients with a previously untreated neck. We aimed to investigate the feasibility and diagnostic accuracy of SNB and unexpected drainage patterns in patients with cT1‐T2N0 OSCC and a history of previous head and neck cancer comprising treatment of the neck, that is, surgery, radiotherapy, or both. Methods Fifty patients with a previously treated neck diagnosed with a new primary or recurrent cN0 OSCC between 2014 and 2021 were included and retrospectively analyzed. Feasibility was assessed by the rate of successfully performed SNB neck staging procedures. Based on follow‐up data, the diagnostic performance of SNB was evaluated by calculation of negative predictive value (NPV) and false omission rate (FOR). Results A SNB staging procedure was successfully performed in 76% (38/50) of the patients. Technical failures were due to the lack of drainage preoperatively or failure in intraoperative SN detection. In patients successfully staged with SNB, the rate of a positive SN was 13% (5/38). In the SNB‐negative group, no patients were diagnosed with a regional node recurrence during follow‐up, and the NPV and FOR were 100% and 0%, respectively. Unexpected lymphatic drainage occurred in 32% (12/38) of the patients. Conclusion SNB is technically feasible in cT1‐2N0 OSCC patients with a previously treated neck with a high diagnostic accuracy. Importantly, SNB enables the detection of individual and unexpected lymphatic drainage patterns. |
| format | Article |
| id | doaj-art-fe148647a954421ba9d30ccf63b13971 |
| institution | OA Journals |
| issn | 2095-8811 2589-1081 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | World Journal of Otorhinolaryngology-Head and Neck Surgery |
| spelling | doaj-art-fe148647a954421ba9d30ccf63b139712025-08-20T01:58:55ZengWileyWorld Journal of Otorhinolaryngology-Head and Neck Surgery2095-88112589-10812024-12-0110426126910.1002/wjo2.157Feasibility and diagnostic performance of sentinel node biopsy for staging cN0 oral squamous cell carcinoma in a previously treated neckTherese Mørch0Jesper F. Tvedskov1Irene Wessel2Birgitte W. Charabi3Kathrine K. Jakobsen4Christian Grønhøj5Katalin Kiss6Giedrius Lelkaitis7Jann Mortensen8Andreas Kjaer9Christian vonBuchwald10Anders Christensen11Department of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkDepartment of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkDepartment of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkDepartment of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkDepartment of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkDepartment of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkDepartment of Pathology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkDepartment of Pathology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkDepartment of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital—Rigshospitalet & Department of Biomedical Sciences University of Copenhagen Copenhagen DenmarkDepartment of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital—Rigshospitalet & Department of Biomedical Sciences University of Copenhagen Copenhagen DenmarkDepartment of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkDepartment of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital—Rigshospitalet University of Copenhagen Copenhagen DenmarkAbstract Objectives Staging of the cN0 neck with sentinel node biopsy (SNB) in early‐stage oral squamous cell carcinoma (OSCC) is validated in patients with a previously untreated neck. We aimed to investigate the feasibility and diagnostic accuracy of SNB and unexpected drainage patterns in patients with cT1‐T2N0 OSCC and a history of previous head and neck cancer comprising treatment of the neck, that is, surgery, radiotherapy, or both. Methods Fifty patients with a previously treated neck diagnosed with a new primary or recurrent cN0 OSCC between 2014 and 2021 were included and retrospectively analyzed. Feasibility was assessed by the rate of successfully performed SNB neck staging procedures. Based on follow‐up data, the diagnostic performance of SNB was evaluated by calculation of negative predictive value (NPV) and false omission rate (FOR). Results A SNB staging procedure was successfully performed in 76% (38/50) of the patients. Technical failures were due to the lack of drainage preoperatively or failure in intraoperative SN detection. In patients successfully staged with SNB, the rate of a positive SN was 13% (5/38). In the SNB‐negative group, no patients were diagnosed with a regional node recurrence during follow‐up, and the NPV and FOR were 100% and 0%, respectively. Unexpected lymphatic drainage occurred in 32% (12/38) of the patients. Conclusion SNB is technically feasible in cT1‐2N0 OSCC patients with a previously treated neck with a high diagnostic accuracy. Importantly, SNB enables the detection of individual and unexpected lymphatic drainage patterns.https://doi.org/10.1002/wjo2.157neck metastasisneck stagingoral squamous cell carcinomaradiotherapysentinel node biopsy |
| spellingShingle | Therese Mørch Jesper F. Tvedskov Irene Wessel Birgitte W. Charabi Kathrine K. Jakobsen Christian Grønhøj Katalin Kiss Giedrius Lelkaitis Jann Mortensen Andreas Kjaer Christian vonBuchwald Anders Christensen Feasibility and diagnostic performance of sentinel node biopsy for staging cN0 oral squamous cell carcinoma in a previously treated neck World Journal of Otorhinolaryngology-Head and Neck Surgery neck metastasis neck staging oral squamous cell carcinoma radiotherapy sentinel node biopsy |
| title | Feasibility and diagnostic performance of sentinel node biopsy for staging cN0 oral squamous cell carcinoma in a previously treated neck |
| title_full | Feasibility and diagnostic performance of sentinel node biopsy for staging cN0 oral squamous cell carcinoma in a previously treated neck |
| title_fullStr | Feasibility and diagnostic performance of sentinel node biopsy for staging cN0 oral squamous cell carcinoma in a previously treated neck |
| title_full_unstemmed | Feasibility and diagnostic performance of sentinel node biopsy for staging cN0 oral squamous cell carcinoma in a previously treated neck |
| title_short | Feasibility and diagnostic performance of sentinel node biopsy for staging cN0 oral squamous cell carcinoma in a previously treated neck |
| title_sort | feasibility and diagnostic performance of sentinel node biopsy for staging cn0 oral squamous cell carcinoma in a previously treated neck |
| topic | neck metastasis neck staging oral squamous cell carcinoma radiotherapy sentinel node biopsy |
| url | https://doi.org/10.1002/wjo2.157 |
| work_keys_str_mv | AT theresemørch feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT jesperftvedskov feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT irenewessel feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT birgittewcharabi feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT kathrinekjakobsen feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT christiangrønhøj feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT katalinkiss feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT giedriuslelkaitis feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT jannmortensen feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT andreaskjaer feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT christianvonbuchwald feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck AT anderschristensen feasibilityanddiagnosticperformanceofsentinelnodebiopsyforstagingcn0oralsquamouscellcarcinomainapreviouslytreatedneck |