Borrelial phosphomannose isomerase as a cell surface localized protein that retains enzymatic activity and promotes host-pathogen interaction

Borrelial phosphomannose isomerase as a cell surface localized protein that retains enzymatic activity and promotes host-pathogen interaction

ABSTRACT All organisms produce an intracellular Zn2+-dependent enzyme, phosphomannose isomerase (PMI) or mannose-6 phosphate isomerase, that catalyzes the reversible conversion of mannose-6-phosphate and fructose-6-phosphate during sugar metabolism and polysaccharide biosynthesis. Unexpectedly, we d...

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Main Authors: Shraboni Dutta, Vipin S. Rana, Brian T. Backstedt, Anil K. Shakya, Chrysoula Kitsou, Ozlem B. Yas, Alexis A. Smith, Michael H. Ronzetti, Rachel M. Lipman, Sarai Araujo-Aris, Xiuli Yang, Ganesha Rai, Yi-Pin Lin, Osnat Herzberg, Utpal Pal
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mBio
Subjects:
moonlighting
lyme disease pathogen
phosphomannose isomerase
host-pathogen interaction
Online Access:https://journals.asm.org/doi/10.1128/mbio.03609-24
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