The Effect of High-Dose Vitamin D on Inflammatory Markers of ICU Patients with COVID-19
Background: Vitamin D can inhibit hyper-inflammatory responses, and there are mechanistic reasons for vitamin D’s beneficial effects in COVID-19 patients. The aim of the present study was to assess how a single high dose of vitamin D can affect inflammatory markers among COVID-19 patients in critica...
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Shiraz University of Medical Sciences
2024-12-01
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| Series: | International Journal of Nutrition Sciences |
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| Online Access: | https://ijns.sums.ac.ir/article_50451_098c1c62b08055bc0fcde4cf7ca4e654.pdf |
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| author | Mohammad Hossein Zamanian Zohreh Javadfar Shima Moradi Roghayeh Mostafaei Ali Soroush Sahar Cheshmeh Akram Rahimi |
| author_facet | Mohammad Hossein Zamanian Zohreh Javadfar Shima Moradi Roghayeh Mostafaei Ali Soroush Sahar Cheshmeh Akram Rahimi |
| author_sort | Mohammad Hossein Zamanian |
| collection | DOAJ |
| description | Background: Vitamin D can inhibit hyper-inflammatory responses, and there are mechanistic reasons for vitamin D’s beneficial effects in COVID-19 patients. The aim of the present study was to assess how a single high dose of vitamin D can affect inflammatory markers among COVID-19 patients in critical conditions.Methods: A single center, double-blind, randomized clinical trial was conducted on 61 COVID-19 patients admitted to the intensive care units (ICUs). The intervention group received 300,000 IU vitamin D intramuscularly and identically placebo patients were monitored for one week. The levels of lactate dehydrogenase (LDH, IU/mL), C-reactive protein (CRP, mg/L), interleukin-6 (IL-6, Pg/L), lymphocytes, neutrophils, and neutrophil/lymphocyte (N/L) ratios were measured at the start and end of the study.Results: This trial included 44 patients with COVID-19 who had vitamin D deficiency at the start. After a high vitamin D dose intervention, lymphocyte level increased while LDH (IU/mL) and neutrophil levels, and N/L ratio decreased. CRP (mg/L) and IL-6 (Pg/L) levels significantly declined following intervention with a high-dose vitamin D.Conclusion: These findings suggest that high doses of vitamin D may improve inflammatory indices in COVID-19 ICU patients. |
| format | Article |
| id | doaj-art-fe135bf7b5e549ffa1b4870e9999c0cd |
| institution | Kabale University |
| issn | 2538-1873 2538-2829 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Nutrition Sciences |
| spelling | doaj-art-fe135bf7b5e549ffa1b4870e9999c0cd2024-12-08T05:09:16ZengShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18732538-28292024-12-019426026810.30476/ijns.2024.102550.132050451The Effect of High-Dose Vitamin D on Inflammatory Markers of ICU Patients with COVID-19Mohammad Hossein Zamanian0Zohreh Javadfar1Shima Moradi2Roghayeh Mostafaei3Ali Soroush4Sahar Cheshmeh5Akram Rahimi6Department of Infectious Diseases, School of Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, IranClinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Department of Nutrition Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran Department of Nutrition Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran Department of Sports Medicine, Cardiovascular Research Center, Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Molecular and Experimental Nutritional Medicine, University of Potsdam, Nuthetal, GermanyClinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, IranBackground: Vitamin D can inhibit hyper-inflammatory responses, and there are mechanistic reasons for vitamin D’s beneficial effects in COVID-19 patients. The aim of the present study was to assess how a single high dose of vitamin D can affect inflammatory markers among COVID-19 patients in critical conditions.Methods: A single center, double-blind, randomized clinical trial was conducted on 61 COVID-19 patients admitted to the intensive care units (ICUs). The intervention group received 300,000 IU vitamin D intramuscularly and identically placebo patients were monitored for one week. The levels of lactate dehydrogenase (LDH, IU/mL), C-reactive protein (CRP, mg/L), interleukin-6 (IL-6, Pg/L), lymphocytes, neutrophils, and neutrophil/lymphocyte (N/L) ratios were measured at the start and end of the study.Results: This trial included 44 patients with COVID-19 who had vitamin D deficiency at the start. After a high vitamin D dose intervention, lymphocyte level increased while LDH (IU/mL) and neutrophil levels, and N/L ratio decreased. CRP (mg/L) and IL-6 (Pg/L) levels significantly declined following intervention with a high-dose vitamin D.Conclusion: These findings suggest that high doses of vitamin D may improve inflammatory indices in COVID-19 ICU patients.https://ijns.sums.ac.ir/article_50451_098c1c62b08055bc0fcde4cf7ca4e654.pdfvitamin d25(oh)dc-reactive protein interleukin-6covid-19iran |
| spellingShingle | Mohammad Hossein Zamanian Zohreh Javadfar Shima Moradi Roghayeh Mostafaei Ali Soroush Sahar Cheshmeh Akram Rahimi The Effect of High-Dose Vitamin D on Inflammatory Markers of ICU Patients with COVID-19 International Journal of Nutrition Sciences vitamin d 25(oh)d c-reactive protein interleukin-6 covid-19 iran |
| title | The Effect of High-Dose Vitamin D on Inflammatory Markers of ICU Patients with COVID-19 |
| title_full | The Effect of High-Dose Vitamin D on Inflammatory Markers of ICU Patients with COVID-19 |
| title_fullStr | The Effect of High-Dose Vitamin D on Inflammatory Markers of ICU Patients with COVID-19 |
| title_full_unstemmed | The Effect of High-Dose Vitamin D on Inflammatory Markers of ICU Patients with COVID-19 |
| title_short | The Effect of High-Dose Vitamin D on Inflammatory Markers of ICU Patients with COVID-19 |
| title_sort | effect of high dose vitamin d on inflammatory markers of icu patients with covid 19 |
| topic | vitamin d 25(oh)d c-reactive protein interleukin-6 covid-19 iran |
| url | https://ijns.sums.ac.ir/article_50451_098c1c62b08055bc0fcde4cf7ca4e654.pdf |
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