Exploring immunotherapeutic strategies for bacterial and viral diseases
The global socioeconomic and health impacts of microbial diseases cannot be overemphasized. The emergence of the coronavirus in 2019 and the ongoing threat of infectious diseases, such as HIV/AIDS, tuberculosis, and hepatitis, remind us of the impact these infections have on economic stability and g...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2025-07-01
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| Series: | Exploration of Immunology |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A1003202/1003202.pdf |
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| author | Ayodele Isaac Adedokun Olaniyi Abideen Adigun Adamu Muhammad Ibrahim Ibrahim Idris Paul Yiran Ntasin Babatunde Ibrahim Olowu Chinyere M. Ikele-Awaogu Precious Kehinde Fadele Ernesto Oluwafemi Dibia Olalekan John Okesanya Mohamed Mustaf Ahmed |
| author_facet | Ayodele Isaac Adedokun Olaniyi Abideen Adigun Adamu Muhammad Ibrahim Ibrahim Idris Paul Yiran Ntasin Babatunde Ibrahim Olowu Chinyere M. Ikele-Awaogu Precious Kehinde Fadele Ernesto Oluwafemi Dibia Olalekan John Okesanya Mohamed Mustaf Ahmed |
| author_sort | Ayodele Isaac Adedokun |
| collection | DOAJ |
| description | The global socioeconomic and health impacts of microbial diseases cannot be overemphasized. The emergence of the coronavirus in 2019 and the ongoing threat of infectious diseases, such as HIV/AIDS, tuberculosis, and hepatitis, remind us of the impact these infections have on economic stability and global health. Gaps in the treatment of microbial infections and their contribution to increased mortality necessitate holistic and long-term solutions, as opposed to antibiotics, which were previously relied upon. Immunotherapy is becoming increasingly promising for the treatment of microbial infections. This study reviews recent advances in immunotherapeutic strategies, particularly cytokine-based therapies, adoptive cell therapy, monoclonal antibodies, and immune checkpoint inhibitors, for the control of antimicrobial resistance. New inventive approaches, such as chimeric antigen receptor T cell therapy and mucosal-associated invariant T cells, have been discussed in the context of bacterial and viral infections, highlighting promising results from clinical trials and addressing the challenges of toxicity, immune evasion, and therapy resistance that are inherent in these diseases. Future priorities include optimizing combination therapies and exploring new immunomodulatory targets to improve the effectiveness of these interventions in treating antimicrobial resistance and other infectious diseases. |
| format | Article |
| id | doaj-art-fe0e8fb971e64152bf6d528542744770 |
| institution | Kabale University |
| issn | 2768-6655 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj-art-fe0e8fb971e64152bf6d5285427447702025-08-20T03:50:16ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552025-07-015100320210.37349/ei.2025.1003202Exploring immunotherapeutic strategies for bacterial and viral diseasesAyodele Isaac Adedokun0https://orcid.org/0000-0003-1875-7098Olaniyi Abideen Adigun1https://orcid.org/0000-0002-2375-6375Adamu Muhammad Ibrahim2https://orcid.org/0000-0003-3657-7541Ibrahim Idris3https://orcid.org/0000-0003-2435-9870Paul Yiran Ntasin4https://orcid.org/0000-0002-0855-1005Babatunde Ibrahim Olowu5https://orcid.org/0000-0003-1406-8359Chinyere M. Ikele-Awaogu6https://orcid.org/0000-0001-6807-7248Precious Kehinde Fadele7https://orcid.org/0000-0002-0464-4167Ernesto Oluwafemi Dibia8https://orcid.org/0000-0002-6247-5840Olalekan John Okesanya9https://orcid.org/0000-0002-3809-4271Mohamed Mustaf Ahmed10https://orcid.org/0009-0006-5991-4052Department of Chemical Pathology, School of Medical Laboratory Science, Usmanu Danfodiyo University Sokoto, Sokoto 2346, NigeriaDepartment of Medical Laboratory Science, Nigerian Defence Academy, Kaduna 2109, NigeriaDepartment of Immunology, School of Medical Laboratory Science, Usmanu Danfodiyo University Sokoto, Sokoto 2346, NigeriaFaculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto 2346, NigeriaInterdisciplinary graduate program in Immunology, University of Iowa, Iowa, IA 52242, United StatesFaculty of Veterinary Medicine, University of Ibadan, Ibadan 200132, NigeriaIntegrated Germline Biology Group Laboratory, Osaka University, Osaka 565-0871, JapanDepartment of Medicine and Surgery, Faculty of Medical Sciences, College of Medicine, University of Nigeria Enugu Campus, Enugu 400241, NigeriaDepartment of Medical Microbiology, University College Hospital, Ibadan 200212, NigeriaDepartment of Public Health and Maritime Transport, Faculty of Medicine, University of Thessaly, 38221 Volos, Greece; Department of Medical Laboratory Science, Chrisland University, Abeokuta 110101, NigeriaFaculty of Medicine and Health Sciences, SIMAD University, Mogadishu 252, SomaliaThe global socioeconomic and health impacts of microbial diseases cannot be overemphasized. The emergence of the coronavirus in 2019 and the ongoing threat of infectious diseases, such as HIV/AIDS, tuberculosis, and hepatitis, remind us of the impact these infections have on economic stability and global health. Gaps in the treatment of microbial infections and their contribution to increased mortality necessitate holistic and long-term solutions, as opposed to antibiotics, which were previously relied upon. Immunotherapy is becoming increasingly promising for the treatment of microbial infections. This study reviews recent advances in immunotherapeutic strategies, particularly cytokine-based therapies, adoptive cell therapy, monoclonal antibodies, and immune checkpoint inhibitors, for the control of antimicrobial resistance. New inventive approaches, such as chimeric antigen receptor T cell therapy and mucosal-associated invariant T cells, have been discussed in the context of bacterial and viral infections, highlighting promising results from clinical trials and addressing the challenges of toxicity, immune evasion, and therapy resistance that are inherent in these diseases. Future priorities include optimizing combination therapies and exploring new immunomodulatory targets to improve the effectiveness of these interventions in treating antimicrobial resistance and other infectious diseases.https://www.explorationpub.com/uploads/Article/A1003202/1003202.pdfcoronavirusimmunotherapyglobal healthmicrobial infectionsdiseases |
| spellingShingle | Ayodele Isaac Adedokun Olaniyi Abideen Adigun Adamu Muhammad Ibrahim Ibrahim Idris Paul Yiran Ntasin Babatunde Ibrahim Olowu Chinyere M. Ikele-Awaogu Precious Kehinde Fadele Ernesto Oluwafemi Dibia Olalekan John Okesanya Mohamed Mustaf Ahmed Exploring immunotherapeutic strategies for bacterial and viral diseases Exploration of Immunology coronavirus immunotherapy global health microbial infections diseases |
| title | Exploring immunotherapeutic strategies for bacterial and viral diseases |
| title_full | Exploring immunotherapeutic strategies for bacterial and viral diseases |
| title_fullStr | Exploring immunotherapeutic strategies for bacterial and viral diseases |
| title_full_unstemmed | Exploring immunotherapeutic strategies for bacterial and viral diseases |
| title_short | Exploring immunotherapeutic strategies for bacterial and viral diseases |
| title_sort | exploring immunotherapeutic strategies for bacterial and viral diseases |
| topic | coronavirus immunotherapy global health microbial infections diseases |
| url | https://www.explorationpub.com/uploads/Article/A1003202/1003202.pdf |
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