The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels
This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3–8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was asses...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2009/532640 |
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| author | J. B. Adams M. Baral E. Geis J. Mitchell J. Ingram A. Hensley I. Zappia S. Newmark E. Gehn R. A. Rubin K. Mitchell J. Bradstreet J. M. El-Dahr |
| author_facet | J. B. Adams M. Baral E. Geis J. Mitchell J. Ingram A. Hensley I. Zappia S. Newmark E. Gehn R. A. Rubin K. Mitchell J. Bradstreet J. M. El-Dahr |
| author_sort | J. B. Adams |
| collection | DOAJ |
| description | This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3–8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted 𝑅2 of 0.22–0.45, 𝑃<.005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals. |
| format | Article |
| id | doaj-art-fe0dc4e4de1348b2bf6a4a6f3705379f |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-fe0dc4e4de1348b2bf6a4a6f3705379f2025-08-20T03:25:47ZengWileyJournal of Toxicology1687-81911687-82052009-01-01200910.1155/2009/532640532640The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione LevelsJ. B. Adams0M. Baral1E. Geis2J. Mitchell3J. Ingram4A. Hensley5I. Zappia6S. Newmark7E. Gehn8R. A. Rubin9K. Mitchell10J. Bradstreet11J. M. El-Dahr12Division of Basic Medical Sciences, Southwest College of Naturopathic Medicine, Tempe, AZ 85282, USADepartment of Pediatric Medicine, Southwest College of Naturopathic Medicine, Tempe, AZ 85282, USAAutism Research Institute, San Diego, CA 92116-2599, USADivision of Basic Medical Sciences, Southwest College of Naturopathic Medicine, Tempe, AZ 85282, USAAutism Research Institute, San Diego, CA 92116-2599, USAAutism Research Institute, San Diego, CA 92116-2599, USAAutism Research Institute, San Diego, CA 92116-2599, USACenter for Integrative Pediatric Medicine, Tucson, AZ 85711, USAAutism Research Institute, San Diego, CA 92116-2599, USADepartment of Mathematics, Whittier College, Whittier, CA 90601-4413, USAAutism Research Institute, San Diego, CA 92116-2599, USADepartment of Pediatric Medicine, Southwest College of Naturopathic Medicine, Tempe, AZ 85282, USADepartment of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USAThis study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3–8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted 𝑅2 of 0.22–0.45, 𝑃<.005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.http://dx.doi.org/10.1155/2009/532640 |
| spellingShingle | J. B. Adams M. Baral E. Geis J. Mitchell J. Ingram A. Hensley I. Zappia S. Newmark E. Gehn R. A. Rubin K. Mitchell J. Bradstreet J. M. El-Dahr The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels Journal of Toxicology |
| title | The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels |
| title_full | The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels |
| title_fullStr | The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels |
| title_full_unstemmed | The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels |
| title_short | The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels |
| title_sort | severity of autism is associated with toxic metal body burden and red blood cell glutathione levels |
| url | http://dx.doi.org/10.1155/2009/532640 |
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