Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates
Resveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. Novel polymeric methoxy-po...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/245625 |
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| author | Yan-Jing Ng Heather A. E. Benson David H. Brown Yan Chen |
| author_facet | Yan-Jing Ng Heather A. E. Benson David H. Brown Yan Chen |
| author_sort | Yan-Jing Ng |
| collection | DOAJ |
| description | Resveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. Novel polymeric methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) RSV conjugates with varying PCL chain lengths have been synthesised and formulated into micelles and/or nanoparticles for preliminary in vitro stability studies. RSV conjugated with mPEG2000-PCL9500 was found to have improved solubility and stability of RSV as compared to RSV alone. The length of the PCL chain was found to affect the micelle formation, hence the stability in physiological buffers and rat plasma. |
| format | Article |
| id | doaj-art-fe0ae06c580745ec9fa07677d8103d51 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-fe0ae06c580745ec9fa07677d8103d512025-02-03T05:44:07ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/245625245625Synthesis and Characterization of Novel Copolymeric Resveratrol ConjugatesYan-Jing Ng0Heather A. E. Benson1David H. Brown2Yan Chen3School of Pharmacy, CHIRI Biosciences, Curtin University, Bentley, WA 6102, AustraliaSchool of Pharmacy, CHIRI Biosciences, Curtin University, Bentley, WA 6102, AustraliaDepartment of Chemistry, Curtin University, Bentley, WA 6102, AustraliaSchool of Pharmacy, CHIRI Biosciences, Curtin University, Bentley, WA 6102, AustraliaResveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. Novel polymeric methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) RSV conjugates with varying PCL chain lengths have been synthesised and formulated into micelles and/or nanoparticles for preliminary in vitro stability studies. RSV conjugated with mPEG2000-PCL9500 was found to have improved solubility and stability of RSV as compared to RSV alone. The length of the PCL chain was found to affect the micelle formation, hence the stability in physiological buffers and rat plasma.http://dx.doi.org/10.1155/2015/245625 |
| spellingShingle | Yan-Jing Ng Heather A. E. Benson David H. Brown Yan Chen Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates Journal of Chemistry |
| title | Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates |
| title_full | Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates |
| title_fullStr | Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates |
| title_full_unstemmed | Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates |
| title_short | Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates |
| title_sort | synthesis and characterization of novel copolymeric resveratrol conjugates |
| url | http://dx.doi.org/10.1155/2015/245625 |
| work_keys_str_mv | AT yanjingng synthesisandcharacterizationofnovelcopolymericresveratrolconjugates AT heatheraebenson synthesisandcharacterizationofnovelcopolymericresveratrolconjugates AT davidhbrown synthesisandcharacterizationofnovelcopolymericresveratrolconjugates AT yanchen synthesisandcharacterizationofnovelcopolymericresveratrolconjugates |