Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease management
RNA therapeutics are emerging as a promising approach for cardiovascular diseases (CVDs) management, offering targeted gene regulation through modalities like mRNA, siRNA, and miRNA. In recent years, researchers have conducted a lot of research on the application of RNA therapeutics technology in th...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1546515/full |
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| _version_ | 1849344313466552320 |
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| author | Wang Dui Zhao Xiaobin Zhang Haifeng Dang Lijuan Huang Wenhui Zhang Zhengfeng Song Jinling |
| author_facet | Wang Dui Zhao Xiaobin Zhang Haifeng Dang Lijuan Huang Wenhui Zhang Zhengfeng Song Jinling |
| author_sort | Wang Dui |
| collection | DOAJ |
| description | RNA therapeutics are emerging as a promising approach for cardiovascular diseases (CVDs) management, offering targeted gene regulation through modalities like mRNA, siRNA, and miRNA. In recent years, researchers have conducted a lot of research on the application of RNA therapeutics technology in the treatment of CVDs. Despite hurdles in off-target effects and immune responses, the clinical trial outcomes are encouraging. This review synthesizes the current progress in RNA therapeutics for CVDs, examining their mechanisms, advantages, and challenges in delivery and safety. We highlight the potential of personalized medicine, combination artificial intelligence (AI) and bioinformatics in advancing RNA therapeutics. The future of RNA therapeutics in CVDs is poised for significant impact, necessitating continued research and interdisciplinary collaboration to optimize these treatments and ensure patient safety and efficacy. |
| format | Article |
| id | doaj-art-fe090b34a9834f51881e9299c1955b86 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-fe090b34a9834f51881e9299c1955b862025-08-20T03:42:41ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-03-011210.3389/fcvm.2025.15465151546515Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease managementWang Dui0Zhao Xiaobin1Zhang Haifeng2Dang Lijuan3Huang Wenhui4Zhang Zhengfeng5Song Jinling6Department of Cardiovascular Rehabilitation, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin, ChinaDepartment of Cardiovascular Rehabilitation, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin, ChinaDepartment of Cardiovascular Rehabilitation, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin, ChinaDepartment of Endocrinology, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin, ChinaCardiovascular Department, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin, ChinaDepartment of Cardiovascular Rehabilitation, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin, ChinaDepartment of Cardiovascular Rehabilitation, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin, ChinaRNA therapeutics are emerging as a promising approach for cardiovascular diseases (CVDs) management, offering targeted gene regulation through modalities like mRNA, siRNA, and miRNA. In recent years, researchers have conducted a lot of research on the application of RNA therapeutics technology in the treatment of CVDs. Despite hurdles in off-target effects and immune responses, the clinical trial outcomes are encouraging. This review synthesizes the current progress in RNA therapeutics for CVDs, examining their mechanisms, advantages, and challenges in delivery and safety. We highlight the potential of personalized medicine, combination artificial intelligence (AI) and bioinformatics in advancing RNA therapeutics. The future of RNA therapeutics in CVDs is poised for significant impact, necessitating continued research and interdisciplinary collaboration to optimize these treatments and ensure patient safety and efficacy.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1546515/fullcardiovascular diseasesRNA therapeuticsmRNAsiRNAmiRNARNA aptamers |
| spellingShingle | Wang Dui Zhao Xiaobin Zhang Haifeng Dang Lijuan Huang Wenhui Zhang Zhengfeng Song Jinling Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease management Frontiers in Cardiovascular Medicine cardiovascular diseases RNA therapeutics mRNA siRNA miRNA RNA aptamers |
| title | Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease management |
| title_full | Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease management |
| title_fullStr | Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease management |
| title_full_unstemmed | Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease management |
| title_short | Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease management |
| title_sort | harnessing rna therapeutics novel approaches and emerging strategies for cardiovascular disease management |
| topic | cardiovascular diseases RNA therapeutics mRNA siRNA miRNA RNA aptamers |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1546515/full |
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