Down-regulation of adenosine monophosphate–activated protein kinase activity: A driver of cancer
Adenosine monophosphate–activated protein kinase (AMPK), a serine/threonine protein kinase, is known as “intracellular energy sensor and regulator.” AMPK regulates multiple cellular processes including protein and lipid synthesis, cell proliferation, invasion, migration, and apoptosis. Moreover, AMP...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317697576 |
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| _version_ | 1850063208389279744 |
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| author | Xiaoling He Cong Li Rong Ke Lingyu Luo Deqiang Huang |
| author_facet | Xiaoling He Cong Li Rong Ke Lingyu Luo Deqiang Huang |
| author_sort | Xiaoling He |
| collection | DOAJ |
| description | Adenosine monophosphate–activated protein kinase (AMPK), a serine/threonine protein kinase, is known as “intracellular energy sensor and regulator.” AMPK regulates multiple cellular processes including protein and lipid synthesis, cell proliferation, invasion, migration, and apoptosis. Moreover, AMPK plays a key role in the regulation of “Warburg effect” in cancer cells. AMPK activity is down-regulated in most tumor tissues compared with the corresponding adjacent paracancerous or normal tissues, indicating that the decline in AMPK activity is closely associated with the development and progression of cancer. Therefore, understanding the mechanism of AMPK deactivation during cancer progression is of pivotal importance as it may identify AMPK as a valid therapeutic target for cancer treatment. Here, we review the mechanisms by which AMPK is down-regulated in cancer. |
| format | Article |
| id | doaj-art-fe073b936f454bcb9dccae87ea73cec3 |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-fe073b936f454bcb9dccae87ea73cec32025-08-20T02:49:43ZengSAGE PublishingTumor Biology1423-03802017-04-013910.1177/1010428317697576Down-regulation of adenosine monophosphate–activated protein kinase activity: A driver of cancerXiaoling HeCong LiRong KeLingyu LuoDeqiang HuangAdenosine monophosphate–activated protein kinase (AMPK), a serine/threonine protein kinase, is known as “intracellular energy sensor and regulator.” AMPK regulates multiple cellular processes including protein and lipid synthesis, cell proliferation, invasion, migration, and apoptosis. Moreover, AMPK plays a key role in the regulation of “Warburg effect” in cancer cells. AMPK activity is down-regulated in most tumor tissues compared with the corresponding adjacent paracancerous or normal tissues, indicating that the decline in AMPK activity is closely associated with the development and progression of cancer. Therefore, understanding the mechanism of AMPK deactivation during cancer progression is of pivotal importance as it may identify AMPK as a valid therapeutic target for cancer treatment. Here, we review the mechanisms by which AMPK is down-regulated in cancer.https://doi.org/10.1177/1010428317697576 |
| spellingShingle | Xiaoling He Cong Li Rong Ke Lingyu Luo Deqiang Huang Down-regulation of adenosine monophosphate–activated protein kinase activity: A driver of cancer Tumor Biology |
| title | Down-regulation of adenosine monophosphate–activated protein kinase activity: A driver of cancer |
| title_full | Down-regulation of adenosine monophosphate–activated protein kinase activity: A driver of cancer |
| title_fullStr | Down-regulation of adenosine monophosphate–activated protein kinase activity: A driver of cancer |
| title_full_unstemmed | Down-regulation of adenosine monophosphate–activated protein kinase activity: A driver of cancer |
| title_short | Down-regulation of adenosine monophosphate–activated protein kinase activity: A driver of cancer |
| title_sort | down regulation of adenosine monophosphate activated protein kinase activity a driver of cancer |
| url | https://doi.org/10.1177/1010428317697576 |
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