KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors

KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors

Abstract Background KRAS-G12C inhibitors mark a notable advancement in targeted cancer therapies, yet identifying predictive biomarkers for treatment efficacy and resistance remains essential for optimizing clinical outcomes. Methods This systematic meta-analysis synthesized studies available throug...

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Bibliographic Details
Main Authors: Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
KRAS-G12C inhibitors
KEAP1 mutations
Biomarkers
Drug resistance
Targeted therapy
Online Access:https://doi.org/10.1186/s12967-025-06089-y
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