Role of nuclear poly(A) binding protein 1 in tumors
Nuclear polyadenosine-binding protein 1(PABPN1)is the only known polyadenosine-binding protein in the cell nucleus of mammals. The first attention was resulted from relevant research on oculopharyngeal muscular dystrophy (OPMD), where mutations and aggregation of PABPN1 were found to be the main pat...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2025-06-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-6-822.pdf |
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| _version_ | 1849710800947642368 |
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| author | SHI Lizhou, HAN Wei, SHEN Xiaojun |
| author_facet | SHI Lizhou, HAN Wei, SHEN Xiaojun |
| author_sort | SHI Lizhou, HAN Wei, SHEN Xiaojun |
| collection | DOAJ |
| description | Nuclear polyadenosine-binding protein 1(PABPN1)is the only known polyadenosine-binding protein in the cell nucleus of mammals. The first attention was resulted from relevant research on oculopharyngeal muscular dystrophy (OPMD), where mutations and aggregation of PABPN1 were found to be the main pathogenesis of the disease. Recently, PABPN1 is found to be abnormally expressed in some tumor tissues, and confirmed to be involved in regulating selective polyadenylation, which leads to the occurrence and development of various human tumors. This article briefly introduces the structure and function of PABPN1, reviews progress of research related to PABPN1 and tumors in recent years, and provide our thought for exploring point potential pathways for future research on the role and mechanism of PABPN1 in the occurrence and development of tumors. |
| format | Article |
| id | doaj-art-fe025b067d0a430dbbc55930d6e09fbf |
| institution | DOAJ |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj-art-fe025b067d0a430dbbc55930d6e09fbf2025-08-20T03:14:49ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252025-06-0145682282810.16352/j.issn.1001-6325.2025.06.0822Role of nuclear poly(A) binding protein 1 in tumorsSHI Lizhou, HAN Wei, SHEN Xiaojun0Department of General Surgery, the First People's Hospital of Kunshan, Gusu School, Nanjing Medical University,Kunshan 215300, ChinaNuclear polyadenosine-binding protein 1(PABPN1)is the only known polyadenosine-binding protein in the cell nucleus of mammals. The first attention was resulted from relevant research on oculopharyngeal muscular dystrophy (OPMD), where mutations and aggregation of PABPN1 were found to be the main pathogenesis of the disease. Recently, PABPN1 is found to be abnormally expressed in some tumor tissues, and confirmed to be involved in regulating selective polyadenylation, which leads to the occurrence and development of various human tumors. This article briefly introduces the structure and function of PABPN1, reviews progress of research related to PABPN1 and tumors in recent years, and provide our thought for exploring point potential pathways for future research on the role and mechanism of PABPN1 in the occurrence and development of tumors.https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-6-822.pdfnuclear poly(a) binding protein 1(pabpn1)|alternative polyadenylation|tumor |
| spellingShingle | SHI Lizhou, HAN Wei, SHEN Xiaojun Role of nuclear poly(A) binding protein 1 in tumors Jichu yixue yu linchuang nuclear poly(a) binding protein 1(pabpn1)|alternative polyadenylation|tumor |
| title | Role of nuclear poly(A) binding protein 1 in tumors |
| title_full | Role of nuclear poly(A) binding protein 1 in tumors |
| title_fullStr | Role of nuclear poly(A) binding protein 1 in tumors |
| title_full_unstemmed | Role of nuclear poly(A) binding protein 1 in tumors |
| title_short | Role of nuclear poly(A) binding protein 1 in tumors |
| title_sort | role of nuclear poly a binding protein 1 in tumors |
| topic | nuclear poly(a) binding protein 1(pabpn1)|alternative polyadenylation|tumor |
| url | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-6-822.pdf |
| work_keys_str_mv | AT shilizhouhanweishenxiaojun roleofnuclearpolyabindingprotein1intumors |