Role of PPARs in Radiation-Induced Brain Injury
Whole-brain irradiation (WBI) represents the primary mode of treatment for brain metastases; about 200 000 patients receive WBI each year in the USA. Up to 50% of adult and 100% of pediatric brain cancer patients who survive >6 months post-WBI will suffer from a progressive, cognitive impairment....
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/234975 |
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| author | Sriram Ramanan Weiling Zhao David R. Riddle Mike E. Robbins |
| author_facet | Sriram Ramanan Weiling Zhao David R. Riddle Mike E. Robbins |
| author_sort | Sriram Ramanan |
| collection | DOAJ |
| description | Whole-brain irradiation (WBI) represents the primary mode of treatment for brain metastases; about 200 000 patients receive WBI each year in the USA. Up to 50% of adult and 100% of pediatric brain cancer patients who survive >6 months post-WBI will suffer from a progressive, cognitive impairment. At present, there are no proven long-term treatments or preventive strategies for this significant radiation-induced late effect. Recent studies suggest that the pathogenesis of
radiation-induced brain injury involves WBI-mediated increases in oxidative stress and/or inflammatory responses in the brain.
Therefore, anti-inflammatory strategies can be employed to modulate radiation-induced brain injury. Peroxisomal
proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the steroid/thyroid hormone
nuclear receptor superfamily. Although traditionally known to play a role in metabolism, increasing evidence suggests a role for
PPARs in regulating the response to inflammation and oxidative injury. PPAR agonists have been shown to cross the blood-brain
barrier and confer neuroprotection in animal models of CNS disorders such as stroke, multiple sclerosis and Parkinson's
disease. However, the role of PPARs in radiation-induced brain injury is unclear. In this manuscript, we review the current
knowledge and the emerging insights about the role of PPARs in modulating radiation-induced brain injury. |
| format | Article |
| id | doaj-art-fe01ecba0d7e4821a8a1067f7917ca68 |
| institution | OA Journals |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-fe01ecba0d7e4821a8a1067f7917ca682025-08-20T02:22:33ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/234975234975Role of PPARs in Radiation-Induced Brain InjurySriram Ramanan0Weiling Zhao1David R. Riddle2Mike E. Robbins3Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USABrain Tumor Center of Excellence, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USABrain Tumor Center of Excellence, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USABrain Tumor Center of Excellence, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USAWhole-brain irradiation (WBI) represents the primary mode of treatment for brain metastases; about 200 000 patients receive WBI each year in the USA. Up to 50% of adult and 100% of pediatric brain cancer patients who survive >6 months post-WBI will suffer from a progressive, cognitive impairment. At present, there are no proven long-term treatments or preventive strategies for this significant radiation-induced late effect. Recent studies suggest that the pathogenesis of radiation-induced brain injury involves WBI-mediated increases in oxidative stress and/or inflammatory responses in the brain. Therefore, anti-inflammatory strategies can be employed to modulate radiation-induced brain injury. Peroxisomal proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the steroid/thyroid hormone nuclear receptor superfamily. Although traditionally known to play a role in metabolism, increasing evidence suggests a role for PPARs in regulating the response to inflammation and oxidative injury. PPAR agonists have been shown to cross the blood-brain barrier and confer neuroprotection in animal models of CNS disorders such as stroke, multiple sclerosis and Parkinson's disease. However, the role of PPARs in radiation-induced brain injury is unclear. In this manuscript, we review the current knowledge and the emerging insights about the role of PPARs in modulating radiation-induced brain injury.http://dx.doi.org/10.1155/2010/234975 |
| spellingShingle | Sriram Ramanan Weiling Zhao David R. Riddle Mike E. Robbins Role of PPARs in Radiation-Induced Brain Injury PPAR Research |
| title | Role of PPARs in Radiation-Induced Brain Injury |
| title_full | Role of PPARs in Radiation-Induced Brain Injury |
| title_fullStr | Role of PPARs in Radiation-Induced Brain Injury |
| title_full_unstemmed | Role of PPARs in Radiation-Induced Brain Injury |
| title_short | Role of PPARs in Radiation-Induced Brain Injury |
| title_sort | role of ppars in radiation induced brain injury |
| url | http://dx.doi.org/10.1155/2010/234975 |
| work_keys_str_mv | AT sriramramanan roleofpparsinradiationinducedbraininjury AT weilingzhao roleofpparsinradiationinducedbraininjury AT davidrriddle roleofpparsinradiationinducedbraininjury AT mikeerobbins roleofpparsinradiationinducedbraininjury |