Role of PPARs in Radiation-Induced Brain Injury
Whole-brain irradiation (WBI) represents the primary mode of treatment for brain metastases; about 200 000 patients receive WBI each year in the USA. Up to 50% of adult and 100% of pediatric brain cancer patients who survive >6 months post-WBI will suffer from a progressive, cognitive impairment....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/234975 |
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| Summary: | Whole-brain irradiation (WBI) represents the primary mode of treatment for brain metastases; about 200 000 patients receive WBI each year in the USA. Up to 50% of adult and 100% of pediatric brain cancer patients who survive >6 months post-WBI will suffer from a progressive, cognitive impairment. At present, there are no proven long-term treatments or preventive strategies for this significant radiation-induced late effect. Recent studies suggest that the pathogenesis of
radiation-induced brain injury involves WBI-mediated increases in oxidative stress and/or inflammatory responses in the brain.
Therefore, anti-inflammatory strategies can be employed to modulate radiation-induced brain injury. Peroxisomal
proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the steroid/thyroid hormone
nuclear receptor superfamily. Although traditionally known to play a role in metabolism, increasing evidence suggests a role for
PPARs in regulating the response to inflammation and oxidative injury. PPAR agonists have been shown to cross the blood-brain
barrier and confer neuroprotection in animal models of CNS disorders such as stroke, multiple sclerosis and Parkinson's
disease. However, the role of PPARs in radiation-induced brain injury is unclear. In this manuscript, we review the current
knowledge and the emerging insights about the role of PPARs in modulating radiation-induced brain injury. |
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| ISSN: | 1687-4757 1687-4765 |