Enhanced microscale NMR spectroscopy of low-gyromagnetic ratio nuclei via hydrogen transfer
Chemical shifts and J-couplings are fundamental parameters in NMR spectroscopy, they provide structural information about molecules. Extracting these quantities from isotopes such as carbon or nitrogen results in reduced sensitivity due to their low gyromagnetic ratios. In this paper, we present a m...
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| Format: | Article |
| Language: | English |
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American Physical Society
2025-06-01
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| Series: | Physical Review Research |
| Online Access: | http://doi.org/10.1103/PhysRevResearch.7.023258 |
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| author | P. Alsina-Bolívar J. Casanova |
| author_facet | P. Alsina-Bolívar J. Casanova |
| author_sort | P. Alsina-Bolívar |
| collection | DOAJ |
| description | Chemical shifts and J-couplings are fundamental parameters in NMR spectroscopy, they provide structural information about molecules. Extracting these quantities from isotopes such as carbon or nitrogen results in reduced sensitivity due to their low gyromagnetic ratios. In this paper, we present a method for detecting chemical shifts and J-couplings at the microscale in low-gyromagnetic-ratio nuclei using NV centers. By leveraging hydrogen nuclei, we achieve strong coupling with NVs and fast signal emission that aligns with NV coherence times. In addition, the technique is well suited for implementations under high magnetic fields. We demonstrate that our protocol achieves a sensitivity enhancement of more than one order of magnitude for scenarios involving ^{13}C, with even greater improvements for nuclei with lower gyromagnetic ratios. |
| format | Article |
| id | doaj-art-fdfea4194f53416a877edceca9c5a9fe |
| institution | Kabale University |
| issn | 2643-1564 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review Research |
| spelling | doaj-art-fdfea4194f53416a877edceca9c5a9fe2025-08-20T03:25:58ZengAmerican Physical SocietyPhysical Review Research2643-15642025-06-017202325810.1103/PhysRevResearch.7.023258Enhanced microscale NMR spectroscopy of low-gyromagnetic ratio nuclei via hydrogen transferP. Alsina-BolívarJ. CasanovaChemical shifts and J-couplings are fundamental parameters in NMR spectroscopy, they provide structural information about molecules. Extracting these quantities from isotopes such as carbon or nitrogen results in reduced sensitivity due to their low gyromagnetic ratios. In this paper, we present a method for detecting chemical shifts and J-couplings at the microscale in low-gyromagnetic-ratio nuclei using NV centers. By leveraging hydrogen nuclei, we achieve strong coupling with NVs and fast signal emission that aligns with NV coherence times. In addition, the technique is well suited for implementations under high magnetic fields. We demonstrate that our protocol achieves a sensitivity enhancement of more than one order of magnitude for scenarios involving ^{13}C, with even greater improvements for nuclei with lower gyromagnetic ratios.http://doi.org/10.1103/PhysRevResearch.7.023258 |
| spellingShingle | P. Alsina-Bolívar J. Casanova Enhanced microscale NMR spectroscopy of low-gyromagnetic ratio nuclei via hydrogen transfer Physical Review Research |
| title | Enhanced microscale NMR spectroscopy of low-gyromagnetic ratio nuclei via hydrogen transfer |
| title_full | Enhanced microscale NMR spectroscopy of low-gyromagnetic ratio nuclei via hydrogen transfer |
| title_fullStr | Enhanced microscale NMR spectroscopy of low-gyromagnetic ratio nuclei via hydrogen transfer |
| title_full_unstemmed | Enhanced microscale NMR spectroscopy of low-gyromagnetic ratio nuclei via hydrogen transfer |
| title_short | Enhanced microscale NMR spectroscopy of low-gyromagnetic ratio nuclei via hydrogen transfer |
| title_sort | enhanced microscale nmr spectroscopy of low gyromagnetic ratio nuclei via hydrogen transfer |
| url | http://doi.org/10.1103/PhysRevResearch.7.023258 |
| work_keys_str_mv | AT palsinabolivar enhancedmicroscalenmrspectroscopyoflowgyromagneticrationucleiviahydrogentransfer AT jcasanova enhancedmicroscalenmrspectroscopyoflowgyromagneticrationucleiviahydrogentransfer |