Molecular signatures of disulfidptosis: interplay with programmed cell death pathways and therapeutic implications in oncology

Molecular signatures of disulfidptosis: interplay with programmed cell death pathways and therapeutic implications in oncology

Abstract Disulfidptosis represents a newly identified form of regulated cell death (RCD) distinct from other well-established RCD pathways. It occurs during periods of glucose starvation, specifically when intracellular NADPH is rapidly depleted and the expression of Solute Carrier Family 7 Member 1...

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Main Authors: Yingchao Liu, Sainan Li, Yunyi Wu, Ping Zhang, Yanhua Yu, Xi Chen, Lingyan Yu, Xinyi Yang, Huanjuan Li, Cuiyun Wu, Jing Du, Yanchun Li
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cellular & Molecular Biology Letters
Subjects:
Disulfidptosis
SLC7 A11
NADPH
Programmed cell death
Cancer therapy
Online Access:https://doi.org/10.1186/s11658-025-00743-5
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