Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation

Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation

Background & Aims: Hepatic steatosis, characterized by lipid accumulation in hepatocytes, is a key diagnostic feature in patients with chronic hepatitis C virus (HCV) infection. This study aimed to clarify the involvement of phospholipid metabolic pathways in the pathogenesis of HCV-induced...

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Bibliographic Details
Main Authors: Masahiko Ito, Jie Liu, Masayoshi Fukasawa, Koji Tsutsumi, Yumi Kanegae, Mitsutoshi Setou, Michinori Kohara, Tetsuro Suzuki
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:JHEP Reports
Subjects:
HCV
liver steatosis
human hepatocyte chimeric mice
lipidome analysis
PLA2G4C
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924002295
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