Gestational Diabetes and Thyroid Autoimmunity
Background. About 10% of pregnancies are complicated by previously unknown impairment of glucose metabolism, which is defined as gestational diabetes. There are little data available on prevalence of thyroid disorders in patients affected by gestational diabetes, and about their postgestational thyr...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/867415 |
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| author | Ester Vitacolonna Annunziata Lapolla Barbara Di Nenno Annalisa Passante Ines Bucci Cesidio Giuliani Dominique Cerrone Fabio Capani Fabrizio Monaco Giorgio Napolitano |
| author_facet | Ester Vitacolonna Annunziata Lapolla Barbara Di Nenno Annalisa Passante Ines Bucci Cesidio Giuliani Dominique Cerrone Fabio Capani Fabrizio Monaco Giorgio Napolitano |
| author_sort | Ester Vitacolonna |
| collection | DOAJ |
| description | Background. About 10% of pregnancies are complicated by previously unknown impairment of glucose metabolism, which is defined as gestational diabetes. There are little data available on prevalence of thyroid disorders in patients affected by gestational diabetes, and about their postgestational thyroid function and autoimmunity. We therefore investigated pancreatic and thyroid autoimmunity in gestational diabetic patients and in women who had had a previous gestational diabetic pregnancy. Methods. We investigated 126 pregnant women at the time of a 100-g oral glucose tolerance test: 91 were classified as gestational diabetics, and 35 were negative (controls). We also studied 69 women who had delivered a baby 18–120 months prior to this investigation and who were classified at that time gestational diabetics (38 women) or normally pregnant (31 women; controls). Results. Our data show no differences for both thyroid function and prevalence of autoimmune disorders during pregnancy; however, a significant increase in thyroid autoimmunity was seen in women previously affected by gestational diabetes. This increased prevalence of thyroid autoimmunity was not associated with the development of impaired glucose metabolism after pregnancy. Conclusions. Our data suggest that maternal hyperglycemia is a risk factor for the development of thyroid autoimmunity, a conclusion that should now be confirmed in a larger cohort of patients. |
| format | Article |
| id | doaj-art-fded55b409214994926b4883cfe0d15b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-fded55b409214994926b4883cfe0d15b2025-02-03T06:00:33ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/867415867415Gestational Diabetes and Thyroid AutoimmunityEster Vitacolonna0Annunziata Lapolla1Barbara Di Nenno2Annalisa Passante3Ines Bucci4Cesidio Giuliani5Dominique Cerrone6Fabio Capani7Fabrizio Monaco8Giorgio Napolitano9Clinical Research Center (CRC), “Gabriele d'Annunzio” University Foundation, 66013 Chieti, ItalyChair of Metabolic Diseases, Department of Clinical and Surgical Sciences, University of Padua, 35122 Padua, ItalySection of Endocrinology, Centre for Aging Sciences (CESI), “Gabriele d'Annunzio” University Foundation, 66013 Chieti, ItalySection of Endocrinology, Centre for Aging Sciences (CESI), “Gabriele d'Annunzio” University Foundation, 66013 Chieti, ItalySection of Endocrinology, Centre for Aging Sciences (CESI), “Gabriele d'Annunzio” University Foundation, 66013 Chieti, ItalySection of Endocrinology, Centre for Aging Sciences (CESI), “Gabriele d'Annunzio” University Foundation, 66013 Chieti, ItalySection of Endocrinology, Centre for Aging Sciences (CESI), “Gabriele d'Annunzio” University Foundation, 66013 Chieti, Italy“Leonardo da Vinci” Online University, Torrevecchia Teatina, 66013 Chieti, ItalySection of Endocrinology, Centre for Aging Sciences (CESI), “Gabriele d'Annunzio” University Foundation, 66013 Chieti, ItalySection of Endocrinology, Centre for Aging Sciences (CESI), “Gabriele d'Annunzio” University Foundation, 66013 Chieti, ItalyBackground. About 10% of pregnancies are complicated by previously unknown impairment of glucose metabolism, which is defined as gestational diabetes. There are little data available on prevalence of thyroid disorders in patients affected by gestational diabetes, and about their postgestational thyroid function and autoimmunity. We therefore investigated pancreatic and thyroid autoimmunity in gestational diabetic patients and in women who had had a previous gestational diabetic pregnancy. Methods. We investigated 126 pregnant women at the time of a 100-g oral glucose tolerance test: 91 were classified as gestational diabetics, and 35 were negative (controls). We also studied 69 women who had delivered a baby 18–120 months prior to this investigation and who were classified at that time gestational diabetics (38 women) or normally pregnant (31 women; controls). Results. Our data show no differences for both thyroid function and prevalence of autoimmune disorders during pregnancy; however, a significant increase in thyroid autoimmunity was seen in women previously affected by gestational diabetes. This increased prevalence of thyroid autoimmunity was not associated with the development of impaired glucose metabolism after pregnancy. Conclusions. Our data suggest that maternal hyperglycemia is a risk factor for the development of thyroid autoimmunity, a conclusion that should now be confirmed in a larger cohort of patients.http://dx.doi.org/10.1155/2012/867415 |
| spellingShingle | Ester Vitacolonna Annunziata Lapolla Barbara Di Nenno Annalisa Passante Ines Bucci Cesidio Giuliani Dominique Cerrone Fabio Capani Fabrizio Monaco Giorgio Napolitano Gestational Diabetes and Thyroid Autoimmunity International Journal of Endocrinology |
| title | Gestational Diabetes and Thyroid Autoimmunity |
| title_full | Gestational Diabetes and Thyroid Autoimmunity |
| title_fullStr | Gestational Diabetes and Thyroid Autoimmunity |
| title_full_unstemmed | Gestational Diabetes and Thyroid Autoimmunity |
| title_short | Gestational Diabetes and Thyroid Autoimmunity |
| title_sort | gestational diabetes and thyroid autoimmunity |
| url | http://dx.doi.org/10.1155/2012/867415 |
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