Cellular senescence in colorectal cancer: its occurrence, effect and therapy

Cellular senescence in colorectal cancer: its occurrence, effect and therapy

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. Although the use of small molecule drugs or targeted drugs has shown significant efficacy in the treatment of CRC, the drug resistance after treatment and the high recurrence and metastasis rate are the key obstacles affec...

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Bibliographic Details
Main Authors: Yabing Liang, Miao Wang, Xianjue Wang, Zhiqing Yang, Shucheng Wang, Fengyi Li, Liya Su, Ling Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
senescence
therapy-induced senescence
senescence-associated secretory phenotype
tumor microenvironment
senolytics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1580951/full
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