Inetetamab triggers cardiotoxicity through its interaction with apoptosis, oxidative stress and autophagy pathways

Inetetamab triggers cardiotoxicity through its interaction with apoptosis, oxidative stress and autophagy pathways

Abstract Inetetamab, a trastuzumab biosimilar, has obtained approval for the treatment of HER2-positive advanced metastatic breast cancer. Despite studies indicating its cardiotoxic properties, the intricate mechanisms underlying its toxicity remain elusive. In the present study, we demonstrated in...

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Bibliographic Details
Main Authors: Weiqun Wang, Hongliang Zhang, Yikun Qu, Yue Li, Peng Peng, Chengbo Lu, Xinyue Zhao, Ziteng Cai, Chaonan Peng, Xiaoli Guo, Yuxin Guo, Jie Li, Xuebin Li, Linlin Jia, Guangyuan Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Inetetamab
Cardiotoxicity
Oxidative stress
Apoptosis
Autophagy
Online Access:https://doi.org/10.1038/s41598-025-02125-5
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