Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies
Breast and ovarian cancers are among the most prevalent cancers in women. Cancerous cells are characterized by their ability to continuously cycle and migrate, forming metastases. Some probiotic strains have shown anti-tumorigenic effects. This study tested the impact of probiotics on OVCAR-3 and MD...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/5/657 |
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| author | Chiara Giorgi Francesca Lombardi Francesca Rosaria Augello Ylli Alicka Massimiliano Quintiliani Skender Topi Annamaria Cimini Vanessa Castelli Michele d’Angelo |
| author_facet | Chiara Giorgi Francesca Lombardi Francesca Rosaria Augello Ylli Alicka Massimiliano Quintiliani Skender Topi Annamaria Cimini Vanessa Castelli Michele d’Angelo |
| author_sort | Chiara Giorgi |
| collection | DOAJ |
| description | Breast and ovarian cancers are among the most prevalent cancers in women. Cancerous cells are characterized by their ability to continuously cycle and migrate, forming metastases. Some probiotic strains have shown anti-tumorigenic effects. This study tested the impact of probiotics on OVCAR-3 and MDA-MB-231 cell lines by analyzing proteins involved in cell cycle regulation (pP53, Cyclin D1, pERK1), cell survival (AKT), and cell migration (RhoA) using Western blotting and scratch wound tests. Results indicated a reduction in these proteins and decreased cell migration velocity post-treatment. These findings suggest that certain probiotic combinations can arrest the cell cycle, promote cell death, and reduce cell migration, potentially serving as promising candidates alongside standard therapies. |
| format | Article |
| id | doaj-art-fdd8484d6df8480eb7d34cdee3270eaa |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-fdd8484d6df8480eb7d34cdee3270eaa2025-08-20T02:33:30ZengMDPI AGBiomolecules2218-273X2025-05-0115565710.3390/biom15050657Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture StudiesChiara Giorgi0Francesca Lombardi1Francesca Rosaria Augello2Ylli Alicka3Massimiliano Quintiliani4Skender Topi5Annamaria Cimini6Vanessa Castelli7Michele d’Angelo8Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Clinical Disciplines, University “Alexander Xhuvani” of Elbasan, 3001 Elbasan, AlbaniaDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Clinical Disciplines, University “Alexander Xhuvani” of Elbasan, 3001 Elbasan, AlbaniaDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyBreast and ovarian cancers are among the most prevalent cancers in women. Cancerous cells are characterized by their ability to continuously cycle and migrate, forming metastases. Some probiotic strains have shown anti-tumorigenic effects. This study tested the impact of probiotics on OVCAR-3 and MDA-MB-231 cell lines by analyzing proteins involved in cell cycle regulation (pP53, Cyclin D1, pERK1), cell survival (AKT), and cell migration (RhoA) using Western blotting and scratch wound tests. Results indicated a reduction in these proteins and decreased cell migration velocity post-treatment. These findings suggest that certain probiotic combinations can arrest the cell cycle, promote cell death, and reduce cell migration, potentially serving as promising candidates alongside standard therapies.https://www.mdpi.com/2218-273X/15/5/657migrationcancercell cycletriple negativebreast cancerovarian cancer |
| spellingShingle | Chiara Giorgi Francesca Lombardi Francesca Rosaria Augello Ylli Alicka Massimiliano Quintiliani Skender Topi Annamaria Cimini Vanessa Castelli Michele d’Angelo Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies Biomolecules migration cancer cell cycle triple negative breast cancer ovarian cancer |
| title | Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies |
| title_full | Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies |
| title_fullStr | Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies |
| title_full_unstemmed | Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies |
| title_short | Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies |
| title_sort | probiotics as anti tumor agents insights from female tumor cell culture studies |
| topic | migration cancer cell cycle triple negative breast cancer ovarian cancer |
| url | https://www.mdpi.com/2218-273X/15/5/657 |
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