Effects of lithium nickel manganese cobalt oxide exposure on biological age acceleration: Insights from metabolomics
The Lithium nickel manganese cobalt oxide (NCM) is a representative new energy material widely used in industry and daily life, but the systemic health influence of exposure to NCM remained largely unknown. This study aimed to reveal the impacts of NCM exposure on biological age acceleration (BAA) a...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325010784 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849390799663398912 |
|---|---|
| author | Wanlu Liu Yaotang Deng Guoliang Li Le Yang Youyi Wu Yue Hu Jieyi Yang Simin Xian Mushi Yi Qiaoyuan Yang Yansen Bai Lili Liu |
| author_facet | Wanlu Liu Yaotang Deng Guoliang Li Le Yang Youyi Wu Yue Hu Jieyi Yang Simin Xian Mushi Yi Qiaoyuan Yang Yansen Bai Lili Liu |
| author_sort | Wanlu Liu |
| collection | DOAJ |
| description | The Lithium nickel manganese cobalt oxide (NCM) is a representative new energy material widely used in industry and daily life, but the systemic health influence of exposure to NCM remained largely unknown. This study aimed to reveal the impacts of NCM exposure on biological age acceleration (BAA) and metabolic alteration, as well as the mediating roles of metabolites. NCM exposure was assessed through three methods: external exposure, biomarker of exposure to NCM mixture (Li, Ni, Co, and Mn), with a particular focus on Li exposure. BAA was calculated using the Klemera and Doubal methods, and untargeted metabolomics was conducted among a representative sample of participants (n = 100). High NCM external exposure showed higher BAA than those with low exposure (median BAA: 0.11 vs. −0.32 years), and increased dose-response relationships between NCM exposure biomarker and BAA were observed using two multi-exposure models. Li was the critical component to NCM exposure effects (weight = 0.793). The “meet-in-the-middle” approach identified twenty-eight metabolites associated with both external and biomarkers of exposure to NCM, Li exposure, and BAA (VIP ≥ 1 and FDR ≤ 0.05). Five key metabolites including TG(50:0)-TG(18:0/16:0/16:0), eicosadienoic acid, Gly-Glu, 2-Oxoarginine, and TG(55:1)-TG(16:0/18:1/21:0) mediated 18.10 %-89.40 % of NCM exposure-BAA association. Our findings provide epidemiological evidence on the hazardous NCM exposure and shed light on metabolic biomarkers for the identification and intervention of accelerated aging among populations. |
| format | Article |
| id | doaj-art-fdcdafa20ec5475b9dd81569849f7f65 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-fdcdafa20ec5475b9dd81569849f7f652025-08-20T03:41:19ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211873310.1016/j.ecoenv.2025.118733Effects of lithium nickel manganese cobalt oxide exposure on biological age acceleration: Insights from metabolomicsWanlu Liu0Yaotang Deng1Guoliang Li2Le Yang3Youyi Wu4Yue Hu5Jieyi Yang6Simin Xian7Mushi Yi8Qiaoyuan Yang9Yansen Bai10Lili Liu11Department of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, ChinaDepartment of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, ChinaDepartment of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, ChinaDepartment of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, ChinaDepartment of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, ChinaDepartment of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, ChinaDepartment of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, ChinaDepartment of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, ChinaDepartment of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, ChinaInstitute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, ChinaInstitute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China; Corresponding authors.Department of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China; Corresponding authors.The Lithium nickel manganese cobalt oxide (NCM) is a representative new energy material widely used in industry and daily life, but the systemic health influence of exposure to NCM remained largely unknown. This study aimed to reveal the impacts of NCM exposure on biological age acceleration (BAA) and metabolic alteration, as well as the mediating roles of metabolites. NCM exposure was assessed through three methods: external exposure, biomarker of exposure to NCM mixture (Li, Ni, Co, and Mn), with a particular focus on Li exposure. BAA was calculated using the Klemera and Doubal methods, and untargeted metabolomics was conducted among a representative sample of participants (n = 100). High NCM external exposure showed higher BAA than those with low exposure (median BAA: 0.11 vs. −0.32 years), and increased dose-response relationships between NCM exposure biomarker and BAA were observed using two multi-exposure models. Li was the critical component to NCM exposure effects (weight = 0.793). The “meet-in-the-middle” approach identified twenty-eight metabolites associated with both external and biomarkers of exposure to NCM, Li exposure, and BAA (VIP ≥ 1 and FDR ≤ 0.05). Five key metabolites including TG(50:0)-TG(18:0/16:0/16:0), eicosadienoic acid, Gly-Glu, 2-Oxoarginine, and TG(55:1)-TG(16:0/18:1/21:0) mediated 18.10 %-89.40 % of NCM exposure-BAA association. Our findings provide epidemiological evidence on the hazardous NCM exposure and shed light on metabolic biomarkers for the identification and intervention of accelerated aging among populations.http://www.sciencedirect.com/science/article/pii/S0147651325010784Lithium nickel manganese cobalt oxideBiological age accelerationMetabolomicsMediation effect |
| spellingShingle | Wanlu Liu Yaotang Deng Guoliang Li Le Yang Youyi Wu Yue Hu Jieyi Yang Simin Xian Mushi Yi Qiaoyuan Yang Yansen Bai Lili Liu Effects of lithium nickel manganese cobalt oxide exposure on biological age acceleration: Insights from metabolomics Ecotoxicology and Environmental Safety Lithium nickel manganese cobalt oxide Biological age acceleration Metabolomics Mediation effect |
| title | Effects of lithium nickel manganese cobalt oxide exposure on biological age acceleration: Insights from metabolomics |
| title_full | Effects of lithium nickel manganese cobalt oxide exposure on biological age acceleration: Insights from metabolomics |
| title_fullStr | Effects of lithium nickel manganese cobalt oxide exposure on biological age acceleration: Insights from metabolomics |
| title_full_unstemmed | Effects of lithium nickel manganese cobalt oxide exposure on biological age acceleration: Insights from metabolomics |
| title_short | Effects of lithium nickel manganese cobalt oxide exposure on biological age acceleration: Insights from metabolomics |
| title_sort | effects of lithium nickel manganese cobalt oxide exposure on biological age acceleration insights from metabolomics |
| topic | Lithium nickel manganese cobalt oxide Biological age acceleration Metabolomics Mediation effect |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325010784 |
| work_keys_str_mv | AT wanluliu effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT yaotangdeng effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT guoliangli effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT leyang effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT youyiwu effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT yuehu effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT jieyiyang effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT siminxian effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT mushiyi effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT qiaoyuanyang effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT yansenbai effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics AT lililiu effectsoflithiumnickelmanganesecobaltoxideexposureonbiologicalageaccelerationinsightsfrommetabolomics |