Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases
Abstract Mitochondria are versatile and complex organelles that can continuously communicate and interact with the cellular milieu. Deregulated communication between mitochondria and host cells/organelles has significant consequences and is an underlying factor of many pathophysiological conditions,...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-024-00669-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850253767430111232 |
|---|---|
| author | Meng Zhang Jin Wei Chang He Liutao Sui Chucheng Jiao Xiaoyan Zhu Xudong Pan |
| author_facet | Meng Zhang Jin Wei Chang He Liutao Sui Chucheng Jiao Xiaoyan Zhu Xudong Pan |
| author_sort | Meng Zhang |
| collection | DOAJ |
| description | Abstract Mitochondria are versatile and complex organelles that can continuously communicate and interact with the cellular milieu. Deregulated communication between mitochondria and host cells/organelles has significant consequences and is an underlying factor of many pathophysiological conditions, including the process of aging. During aging, mitochondria lose function, and mitocellular communication pathways break down; mitochondrial dysfunction interacts with mitochondrial dyscommunication, forming a vicious circle. Therefore, strategies to protect mitochondrial function and promote effective communication of mitochondria can increase healthy lifespan and longevity, which might be a new treatment paradigm for age-related disorders. In this review, we comprehensively discuss the signal transduction mechanisms of inter- and intracellular mitochondrial communication, as well as the interactions between mitochondrial communication and the hallmarks of aging. This review emphasizes the indispensable position of inter- and intracellular mitochondrial communication in the aging process of organisms, which is crucial as the cellular signaling hubs. In addition, we also specifically focus on the status of mitochondria-targeted interventions to provide potential therapeutic targets for age-related diseases. Graphical Abstract |
| format | Article |
| id | doaj-art-fdc6ce697ebd4bcdab77f063d8998f7b |
| institution | OA Journals |
| issn | 1689-1392 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj-art-fdc6ce697ebd4bcdab77f063d8998f7b2025-08-20T01:57:16ZengBMCCellular & Molecular Biology Letters1689-13922024-12-0129113410.1186/s11658-024-00669-4Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseasesMeng Zhang0Jin Wei1Chang He2Liutao Sui3Chucheng Jiao4Xiaoyan Zhu5Xudong Pan6Department of Neurology, The Affiliated Hospital of Qingdao UniversityDepartment of Neurology, The Affiliated Hospital of Qingdao UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Qingdao UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Qingdao UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Qingdao UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Qingdao UniversityDepartment of Neurology, The Affiliated Hospital of Qingdao UniversityAbstract Mitochondria are versatile and complex organelles that can continuously communicate and interact with the cellular milieu. Deregulated communication between mitochondria and host cells/organelles has significant consequences and is an underlying factor of many pathophysiological conditions, including the process of aging. During aging, mitochondria lose function, and mitocellular communication pathways break down; mitochondrial dysfunction interacts with mitochondrial dyscommunication, forming a vicious circle. Therefore, strategies to protect mitochondrial function and promote effective communication of mitochondria can increase healthy lifespan and longevity, which might be a new treatment paradigm for age-related disorders. In this review, we comprehensively discuss the signal transduction mechanisms of inter- and intracellular mitochondrial communication, as well as the interactions between mitochondrial communication and the hallmarks of aging. This review emphasizes the indispensable position of inter- and intracellular mitochondrial communication in the aging process of organisms, which is crucial as the cellular signaling hubs. In addition, we also specifically focus on the status of mitochondria-targeted interventions to provide potential therapeutic targets for age-related diseases. Graphical Abstracthttps://doi.org/10.1186/s11658-024-00669-4Mitochondrial communicationMitochondrial dysfunctionAgingAge-related diseasesSignaling hubs |
| spellingShingle | Meng Zhang Jin Wei Chang He Liutao Sui Chucheng Jiao Xiaoyan Zhu Xudong Pan Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases Cellular & Molecular Biology Letters Mitochondrial communication Mitochondrial dysfunction Aging Age-related diseases Signaling hubs |
| title | Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases |
| title_full | Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases |
| title_fullStr | Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases |
| title_full_unstemmed | Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases |
| title_short | Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases |
| title_sort | inter and intracellular mitochondrial communication signaling hubs in aging and age related diseases |
| topic | Mitochondrial communication Mitochondrial dysfunction Aging Age-related diseases Signaling hubs |
| url | https://doi.org/10.1186/s11658-024-00669-4 |
| work_keys_str_mv | AT mengzhang interandintracellularmitochondrialcommunicationsignalinghubsinagingandagerelateddiseases AT jinwei interandintracellularmitochondrialcommunicationsignalinghubsinagingandagerelateddiseases AT changhe interandintracellularmitochondrialcommunicationsignalinghubsinagingandagerelateddiseases AT liutaosui interandintracellularmitochondrialcommunicationsignalinghubsinagingandagerelateddiseases AT chuchengjiao interandintracellularmitochondrialcommunicationsignalinghubsinagingandagerelateddiseases AT xiaoyanzhu interandintracellularmitochondrialcommunicationsignalinghubsinagingandagerelateddiseases AT xudongpan interandintracellularmitochondrialcommunicationsignalinghubsinagingandagerelateddiseases |