Cancer-associated fibroblasts: dual roles from senescence sentinels to death regulators and new dimensions in therapy

Cancer-associated fibroblasts: dual roles from senescence sentinels to death regulators and new dimensions in therapy

Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment (TME), playing a pivotal role in tumor initiation, progression, and therapeutic resistance. This review explores the dual roles of CAFs in regulating tumor cell senescence and cell death, elucidating their mec...

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Bibliographic Details
Main Authors: Guixiang Ruan, Xiang Wang, Huiyi Ou, Duancheng Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
cancer-associated fibroblasts
cell senescence
cell death
SASP
TME
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1635771/full
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