Comparison of Efficacy of Azithromycin with Ciprofloxacin in the Treatment of Uncomplicated Enteric Fever in Children
Objective: To compare the effectiveness of azithromycin to ciprofloxacin in the management of uncomplicated enteric fever in children between 6-12 years of age in the paediatrics department of Pakistan Atomic Energy Commission (PAEC) General Hospital. Methods: It was a randomized control tri...
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Rawalpindi Medical University
2025-01-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2619 |
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| author | Maimoona Akram Qurrat ul Ain Ayesha Tariq Samra Javed Kiran Nayab Sampana Fatima |
| author_facet | Maimoona Akram Qurrat ul Ain Ayesha Tariq Samra Javed Kiran Nayab Sampana Fatima |
| author_sort | Maimoona Akram |
| collection | DOAJ |
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Objective: To compare the effectiveness of azithromycin to ciprofloxacin in the management of uncomplicated enteric fever in children between 6-12 years of age in the paediatrics department of Pakistan Atomic Energy Commission (PAEC) General Hospital.
Methods: It was a randomized control trial study, conducted at the Department of Pediatrics, PAEC General Hospital, Islamabad from 30-01-21 to 30-07-22. Data from 196 children with signs and symptoms of uncomplicated enteric fever was collected after obtaining verbal consent from their parents. Demographic information of the patients along with a short medical history were noted in pre-designed forms.
Results: Mean age, treatment time, body weight and defervescence time in the azithromycin group were 9.21±2.24 years, 5.87±1.78 days, 28.3±4.54 kg and 49.8±10.21 hours, respectively. Similarly, age, treatment duration, body weight and defervescence time in the ciprofloxacin group were 9.48±2.41 years, 6.41±1.14 days, 26.9±4.89 kg and 53.7±12.25 hours, respectively. The observed efficacy was 92 (93.9%) and 74 (75.5%) in the azithromycin and ciprofloxacin groups, respectively.
Conclusion: Azithromycin is an efficient outdoor patient treatment choice for children with uncomplicated typhoid fever and needs to be widely utilized in high-risk fluoroquinolone-resistant countries.
Keywords: Multi-Drug Resistance; Salmonella Typhi; Azithromycin; Ciprofloxacin.
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| format | Article |
| id | doaj-art-fdaf8cf0e7b64c9582bc6e87f7087f0e |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-fdaf8cf0e7b64c9582bc6e87f7087f0e2025-02-06T08:34:02ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702025-01-0128410.37939/jrmc.v28i4.2619Comparison of Efficacy of Azithromycin with Ciprofloxacin in the Treatment of Uncomplicated Enteric Fever in ChildrenMaimoona AkramQurrat ul AinAyesha Tariq Samra JavedKiran NayabSampana Fatima0Shalamar Medical and Dental College, Lahore Objective: To compare the effectiveness of azithromycin to ciprofloxacin in the management of uncomplicated enteric fever in children between 6-12 years of age in the paediatrics department of Pakistan Atomic Energy Commission (PAEC) General Hospital. Methods: It was a randomized control trial study, conducted at the Department of Pediatrics, PAEC General Hospital, Islamabad from 30-01-21 to 30-07-22. Data from 196 children with signs and symptoms of uncomplicated enteric fever was collected after obtaining verbal consent from their parents. Demographic information of the patients along with a short medical history were noted in pre-designed forms. Results: Mean age, treatment time, body weight and defervescence time in the azithromycin group were 9.21±2.24 years, 5.87±1.78 days, 28.3±4.54 kg and 49.8±10.21 hours, respectively. Similarly, age, treatment duration, body weight and defervescence time in the ciprofloxacin group were 9.48±2.41 years, 6.41±1.14 days, 26.9±4.89 kg and 53.7±12.25 hours, respectively. The observed efficacy was 92 (93.9%) and 74 (75.5%) in the azithromycin and ciprofloxacin groups, respectively. Conclusion: Azithromycin is an efficient outdoor patient treatment choice for children with uncomplicated typhoid fever and needs to be widely utilized in high-risk fluoroquinolone-resistant countries. Keywords: Multi-Drug Resistance; Salmonella Typhi; Azithromycin; Ciprofloxacin. https://www.journalrmc.com/index.php/JRMC/article/view/2619: Enteric Fever, Typhoid Fever, Salmonella Typhi, Multi-Drug Resistance |
| spellingShingle | Maimoona Akram Qurrat ul Ain Ayesha Tariq Samra Javed Kiran Nayab Sampana Fatima Comparison of Efficacy of Azithromycin with Ciprofloxacin in the Treatment of Uncomplicated Enteric Fever in Children Journal of Rawalpindi Medical College : Enteric Fever, Typhoid Fever, Salmonella Typhi, Multi-Drug Resistance |
| title | Comparison of Efficacy of Azithromycin with Ciprofloxacin in the Treatment of Uncomplicated Enteric Fever in Children |
| title_full | Comparison of Efficacy of Azithromycin with Ciprofloxacin in the Treatment of Uncomplicated Enteric Fever in Children |
| title_fullStr | Comparison of Efficacy of Azithromycin with Ciprofloxacin in the Treatment of Uncomplicated Enteric Fever in Children |
| title_full_unstemmed | Comparison of Efficacy of Azithromycin with Ciprofloxacin in the Treatment of Uncomplicated Enteric Fever in Children |
| title_short | Comparison of Efficacy of Azithromycin with Ciprofloxacin in the Treatment of Uncomplicated Enteric Fever in Children |
| title_sort | comparison of efficacy of azithromycin with ciprofloxacin in the treatment of uncomplicated enteric fever in children |
| topic | : Enteric Fever, Typhoid Fever, Salmonella Typhi, Multi-Drug Resistance |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2619 |
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