Human Placental Extract as a Promising Epidural Therapy for Lumbar Spinal Stenosis: Enhancing Axonal Plasticity and Mitigating Pain and Inflammation in a Rat Model

Human Placental Extract as a Promising Epidural Therapy for Lumbar Spinal Stenosis: Enhancing Axonal Plasticity and Mitigating Pain and Inflammation in a Rat Model

ABSTRACT Background Epidural injections treat lumbar spinal stenosis (LSS) by targeting localized inflammation and tissue damage. However, current medications such as corticosteroids and local anesthetics often have limited efficacy and significant adverse effects. Methods Human placental extract (H...

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Main Authors: Jin Young Hong, Hyun Kim, Wan‐Jin Jeon, Changhwan Yeo, Junseon Lee, Hyunseong Kim, Yoon Jae Lee, In‐Hyuk Ha
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:JOR Spine
Subjects:
axonal growth
human placental extract
inflammation
lumbar spinal stenosis
repetitive epidural injections
serotonergic axons
Online Access:https://doi.org/10.1002/jsp2.70085
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