An artificial intelligence-based model for prediction of clonal hematopoiesis variants in cell-free DNA samples

An artificial intelligence-based model for prediction of clonal hematopoiesis variants in cell-free DNA samples

Abstract Circulating tumor DNA is a critical biomarker in cancer diagnostics, but its accurate interpretation requires careful consideration of clonal hematopoiesis (CH), which can contribute to variants in cell-free DNA and potentially obscure true tumor-derived signals. Accurate detection of somat...

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Bibliographic Details
Main Authors: Gustavo Arango-Argoty, Marzieh Haghighi, Gerald J. Sun, Elizabeth Y. Choe, Aleksandra Markovets, J. Carl Barrett, Zhongwu Lai, Etai Jacob
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00921-w
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