Aggravated pneumonia and diabetes in SARS-CoV-2 infected diabetic mice
Multiple clinical and epidemiological studies have shown an interconnection between coronavirus disease 2019 (COVID-19) and diabetes, but experimental evidence is still lacking. Understanding the interplay between them is important because of the global health burden of COVID-19 and diabetes. We fou...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2203782 |
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| author | Qing Huang Ran An Haixuan Wang Yun Yang Cong Tang Junbin Wang Wenhai Yu Yanan Zhou Yongmei Zhang Daoju Wu Bai Li Hao Yang Shuaiyao Lu Xiaozhong Peng |
| author_facet | Qing Huang Ran An Haixuan Wang Yun Yang Cong Tang Junbin Wang Wenhai Yu Yanan Zhou Yongmei Zhang Daoju Wu Bai Li Hao Yang Shuaiyao Lu Xiaozhong Peng |
| author_sort | Qing Huang |
| collection | DOAJ |
| description | Multiple clinical and epidemiological studies have shown an interconnection between coronavirus disease 2019 (COVID-19) and diabetes, but experimental evidence is still lacking. Understanding the interplay between them is important because of the global health burden of COVID-19 and diabetes. We found that C57BL/6J mice were susceptible to the alpha strain of SARS-CoV-2. Moreover, diabetic C57BL/6J mice with leptin receptor gene deficiency (db/db mice) showed a higher viral load in the throat and lung and slower virus clearance in the throat after infection than C57BL/6J mice. Histological and multifactor analysis revealed more advanced pulmonary injury and serum inflammation in SARS-CoV-2 infected diabetic mice. Moreover, SARS-CoV-2 infected diabetic mice exhibited more severe insulin resistance and islet cell loss than uninfected diabetic mice. By RNA sequencing analysis, we found that diabetes may reduce the collagen level, suppress the immune response and aggravate inflammation in the lung after infection, which may account for the greater susceptibility of diabetic mice and their more severe lung damage after infection. In summary, we successfully established a SARS-CoV-2 infected diabetic mice model and demonstrated that diabetes and COVID-19 were risk factors for one another. |
| format | Article |
| id | doaj-art-fd9c5c66a7e54b7e91676d2654b015ea |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-fd9c5c66a7e54b7e91676d2654b015ea2025-08-20T03:52:57ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112110.1080/22221751.2023.2203782Aggravated pneumonia and diabetes in SARS-CoV-2 infected diabetic miceQing Huang0Ran An1Haixuan Wang2Yun Yang3Cong Tang4Junbin Wang5Wenhai Yu6Yanan Zhou7Yongmei Zhang8Daoju Wu9Bai Li10Hao Yang11Shuaiyao Lu12Xiaozhong Peng13Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, People’s Republic of ChinaMultiple clinical and epidemiological studies have shown an interconnection between coronavirus disease 2019 (COVID-19) and diabetes, but experimental evidence is still lacking. Understanding the interplay between them is important because of the global health burden of COVID-19 and diabetes. We found that C57BL/6J mice were susceptible to the alpha strain of SARS-CoV-2. Moreover, diabetic C57BL/6J mice with leptin receptor gene deficiency (db/db mice) showed a higher viral load in the throat and lung and slower virus clearance in the throat after infection than C57BL/6J mice. Histological and multifactor analysis revealed more advanced pulmonary injury and serum inflammation in SARS-CoV-2 infected diabetic mice. Moreover, SARS-CoV-2 infected diabetic mice exhibited more severe insulin resistance and islet cell loss than uninfected diabetic mice. By RNA sequencing analysis, we found that diabetes may reduce the collagen level, suppress the immune response and aggravate inflammation in the lung after infection, which may account for the greater susceptibility of diabetic mice and their more severe lung damage after infection. In summary, we successfully established a SARS-CoV-2 infected diabetic mice model and demonstrated that diabetes and COVID-19 were risk factors for one another.https://www.tandfonline.com/doi/10.1080/22221751.2023.2203782SARS-CoV-2diabetesrisk factormice modelpneumonia |
| spellingShingle | Qing Huang Ran An Haixuan Wang Yun Yang Cong Tang Junbin Wang Wenhai Yu Yanan Zhou Yongmei Zhang Daoju Wu Bai Li Hao Yang Shuaiyao Lu Xiaozhong Peng Aggravated pneumonia and diabetes in SARS-CoV-2 infected diabetic mice Emerging Microbes and Infections SARS-CoV-2 diabetes risk factor mice model pneumonia |
| title | Aggravated pneumonia and diabetes in SARS-CoV-2 infected diabetic mice |
| title_full | Aggravated pneumonia and diabetes in SARS-CoV-2 infected diabetic mice |
| title_fullStr | Aggravated pneumonia and diabetes in SARS-CoV-2 infected diabetic mice |
| title_full_unstemmed | Aggravated pneumonia and diabetes in SARS-CoV-2 infected diabetic mice |
| title_short | Aggravated pneumonia and diabetes in SARS-CoV-2 infected diabetic mice |
| title_sort | aggravated pneumonia and diabetes in sars cov 2 infected diabetic mice |
| topic | SARS-CoV-2 diabetes risk factor mice model pneumonia |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2203782 |
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