Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload
Lithium ascorbate is a lithium salt with normothymic and neuroprotective properties. In an experimental model of non-alcoholic fatty liver disease with multiorgan pathology caused by combined consumption of excessive amounts of saturated fats, carbohydrates and inorganic iron salt, the use of lithiu...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2025-01-01
|
| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/438 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849248602305593344 |
|---|---|
| author | T. E. Bogacheva A. G. Kalacheva O. A. Gromova I. Yu. Torshin T. R. Grishina A. A. Garanin |
| author_facet | T. E. Bogacheva A. G. Kalacheva O. A. Gromova I. Yu. Torshin T. R. Grishina A. A. Garanin |
| author_sort | T. E. Bogacheva |
| collection | DOAJ |
| description | Lithium ascorbate is a lithium salt with normothymic and neuroprotective properties. In an experimental model of non-alcoholic fatty liver disease with multiorgan pathology caused by combined consumption of excessive amounts of saturated fats, carbohydrates and inorganic iron salt, the use of lithium ascorbate showed pronounced hepatoprotective effects. The introduction of lithium ascorbate reduced the level of ferritin and transferrin saturation, the content of serum iron, AST, ALT, serum creatinine, leukocytes and normalized the level of serum protein and the rate of glomerular filtration. Lithium ascorbate reduced the increased content of reticulocytes and platelets to control values, restored the levels of vitamins C, B12 in the blood and reduced the number of Kupffer cells in the liver, which were overloaded with iron. The hepatoprotective effect of lithium ascorbate was confirmed histologically. The ability of the neuroprotector lithium ascorbate to reduce the level of hemosiderosis can be used in the treatment of patients with hepatic encephalopathy. |
| format | Article |
| id | doaj-art-fd9645c7cdfd42e3b54acdf752c05159 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2025-01-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-fd9645c7cdfd42e3b54acdf752c051592025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302025-01-0104495410.37489/2587-7836-2024-4-49-54391Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overloadT. E. Bogacheva0A. G. Kalacheva1O. A. Gromova2I. Yu. Torshin3T. R. Grishina4A. A. Garanin5Ivanovo State Medical University of MOH of RussiaIvanovo State Medical University of MOH of RussiaFederal Research Center «Computer Science and Control», RASFederal Research Center «Computer Science and Control», RASIvanovo State Medical University of MOH of RussiaIvanovo State Medical University of MOH of RussiaLithium ascorbate is a lithium salt with normothymic and neuroprotective properties. In an experimental model of non-alcoholic fatty liver disease with multiorgan pathology caused by combined consumption of excessive amounts of saturated fats, carbohydrates and inorganic iron salt, the use of lithium ascorbate showed pronounced hepatoprotective effects. The introduction of lithium ascorbate reduced the level of ferritin and transferrin saturation, the content of serum iron, AST, ALT, serum creatinine, leukocytes and normalized the level of serum protein and the rate of glomerular filtration. Lithium ascorbate reduced the increased content of reticulocytes and platelets to control values, restored the levels of vitamins C, B12 in the blood and reduced the number of Kupffer cells in the liver, which were overloaded with iron. The hepatoprotective effect of lithium ascorbate was confirmed histologically. The ability of the neuroprotector lithium ascorbate to reduce the level of hemosiderosis can be used in the treatment of patients with hepatic encephalopathy.https://www.pharmacokinetica.ru/jour/article/view/438neuroprotectorsfatty liver diseasehepatoprotectioniron overloadhemosiderosislithium ascorbate |
| spellingShingle | T. E. Bogacheva A. G. Kalacheva O. A. Gromova I. Yu. Torshin T. R. Grishina A. A. Garanin Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload Фармакокинетика и Фармакодинамика neuroprotectors fatty liver disease hepatoprotection iron overload hemosiderosis lithium ascorbate |
| title | Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload |
| title_full | Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload |
| title_fullStr | Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload |
| title_full_unstemmed | Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload |
| title_short | Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload |
| title_sort | нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload |
| topic | neuroprotectors fatty liver disease hepatoprotection iron overload hemosiderosis lithium ascorbate |
| url | https://www.pharmacokinetica.ru/jour/article/view/438 |
| work_keys_str_mv | AT tebogacheva nepatoprotectiveeffectsoflithiumascorbateonamodelofnonalcoholicfattyliverdiseasewithironoverload AT agkalacheva nepatoprotectiveeffectsoflithiumascorbateonamodelofnonalcoholicfattyliverdiseasewithironoverload AT oagromova nepatoprotectiveeffectsoflithiumascorbateonamodelofnonalcoholicfattyliverdiseasewithironoverload AT iyutorshin nepatoprotectiveeffectsoflithiumascorbateonamodelofnonalcoholicfattyliverdiseasewithironoverload AT trgrishina nepatoprotectiveeffectsoflithiumascorbateonamodelofnonalcoholicfattyliverdiseasewithironoverload AT aagaranin nepatoprotectiveeffectsoflithiumascorbateonamodelofnonalcoholicfattyliverdiseasewithironoverload |