TCP1 promotes the progression of malignant tumours by stabilizing c-Myc through the AKT/GSK-3β and ERK signalling pathways

TCP1 promotes the progression of malignant tumours by stabilizing c-Myc through the AKT/GSK-3β and ERK signalling pathways

Abstract The chaperonin tailless complex polypeptide 1 (TCP1) is a key subunit of chaperonin containing TCP1 (CCT) that regulates the folding and stability of proteins during cancer progression. Here, the prognostic significance of TCP1 was explored mainly in patients with hepatocellular carcinoma (...

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Main Authors: Hekun Liu, Linying Chen, Yuwen Chen, Yiyi Jin, Xiance Chen, Nengjun Ma, Fan Yang, Huixia Bi, Xinxin Wen, Shenmin Xu, Juan Chen, Yanping Lin, Yinghong Yang, Yong Wu, Yuanzhong Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07867-6
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