Effects of subanesthetic dose of ketamine on motor and cognitive outcomes of harmaline-induced essential tremor model: a focus on Lingo-1 and inflammatory pathways

Effects of subanesthetic dose of ketamine on motor and cognitive outcomes of harmaline-induced essential tremor model: a focus on Lingo-1 and inflammatory pathways

Abstract Introduction Essential tremor (ET) is a common neurodegenerative disorder characterized by action tremors and various non-motor symptoms. This study investigated the potential therapeutic effects of ketamine, an NMDA receptor antagonist with known GABA modulatory and anti-inflammatory prope...

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Main Authors: Mehran Ilaghi, Zeynab Pirmoradi, Zahra Esmaili, Shamim Hosseinalipour, Leili Rouhi, Adel Soltanizadeh, Mohsen Nakhaie, Kiana Sharififar, Moazamehosadat Razavinasab, Mohammad Shabani
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Neuroscience
Subjects:
Essential tremor
Ketamine
Harmaline. Lingo-1
Inflammation
Online Access:https://doi.org/10.1186/s12868-025-00966-4
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