Morbidity and Mortality Among Very-low-birth-weight Infants Born to Mothers with Clinical Chorioamnionitis
Controversy exists about the relationship between maternal inflammation and the development of different morbidities and mortality in the newborn. We aimed to establish the incidence of clinical chorioamnionitis in our Neonatal Intensive Care Unit and its relation to morbidity and mortality among ve...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-10-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957214000370 |
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| author | Fermín García-Muñoz Rodrigo Gloria M. Galán Henríquez Cristina Gómez Ospina |
| author_facet | Fermín García-Muñoz Rodrigo Gloria M. Galán Henríquez Cristina Gómez Ospina |
| author_sort | Fermín García-Muñoz Rodrigo |
| collection | DOAJ |
| description | Controversy exists about the relationship between maternal inflammation and the development of different morbidities and mortality in the newborn. We aimed to establish the incidence of clinical chorioamnionitis in our Neonatal Intensive Care Unit and its relation to morbidity and mortality among very-low-birth-weight infants.
Methods: This was an observational study of a cohort of very-low-birth-weight neonates admitted to our Neonatal Intensive Care Unit, between January 2008 and December 2012. Demographic characteristics and outcomes were analyzed and a comparison between exposed and non-exposed infants was carried out.
Results: During the study period, 451 very-low-birth-weight infants were admitted to our Neonatal Intensive Care Unit, and 31 (6.87%) were exposed to maternal clinical chorioamnionitis. The incidence was higher at lower gestational ages: 13.2% (23–26 weeks), 8.1% (27–30 weeks), and 2.6% (31–34 weeks) (p = 0.022). After correcting by gestational age and birth weight, early-onset neonatal sepsis (adjusted relative risk = 6.13; 95% confidence interval = 1.67–22.58; p = 0.006) and periventricular leukomalacia (adjusted relative risk = 24.62; 95% confidence interval = 1.87–324.28; p = 0.015) were significantly associated with maternal clinical chorioamnionitis. There were no differences in mortality or in survival without major morbidity.
Conclusion: Clinical chorioamnionitis confers an increased risk of early-onset neonatal sepsis and periventricular leukomalacia to exposed very-low-birth-weight infants. |
| format | Article |
| id | doaj-art-fd82e52f6c274613be9d714896ae7e95 |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-fd82e52f6c274613be9d714896ae7e952025-08-20T03:06:16ZengElsevierPediatrics and Neonatology1875-95722014-10-0155538138610.1016/j.pedneo.2013.12.007Morbidity and Mortality Among Very-low-birth-weight Infants Born to Mothers with Clinical ChorioamnionitisFermín García-Muñoz RodrigoGloria M. Galán HenríquezCristina Gómez OspinaControversy exists about the relationship between maternal inflammation and the development of different morbidities and mortality in the newborn. We aimed to establish the incidence of clinical chorioamnionitis in our Neonatal Intensive Care Unit and its relation to morbidity and mortality among very-low-birth-weight infants. Methods: This was an observational study of a cohort of very-low-birth-weight neonates admitted to our Neonatal Intensive Care Unit, between January 2008 and December 2012. Demographic characteristics and outcomes were analyzed and a comparison between exposed and non-exposed infants was carried out. Results: During the study period, 451 very-low-birth-weight infants were admitted to our Neonatal Intensive Care Unit, and 31 (6.87%) were exposed to maternal clinical chorioamnionitis. The incidence was higher at lower gestational ages: 13.2% (23–26 weeks), 8.1% (27–30 weeks), and 2.6% (31–34 weeks) (p = 0.022). After correcting by gestational age and birth weight, early-onset neonatal sepsis (adjusted relative risk = 6.13; 95% confidence interval = 1.67–22.58; p = 0.006) and periventricular leukomalacia (adjusted relative risk = 24.62; 95% confidence interval = 1.87–324.28; p = 0.015) were significantly associated with maternal clinical chorioamnionitis. There were no differences in mortality or in survival without major morbidity. Conclusion: Clinical chorioamnionitis confers an increased risk of early-onset neonatal sepsis and periventricular leukomalacia to exposed very-low-birth-weight infants.http://www.sciencedirect.com/science/article/pii/S1875957214000370clinical chorioamnionitisearly-onset neonatal sepsismortalitynewbornoutcomeperiventricular leukomalacia |
| spellingShingle | Fermín García-Muñoz Rodrigo Gloria M. Galán Henríquez Cristina Gómez Ospina Morbidity and Mortality Among Very-low-birth-weight Infants Born to Mothers with Clinical Chorioamnionitis Pediatrics and Neonatology clinical chorioamnionitis early-onset neonatal sepsis mortality newborn outcome periventricular leukomalacia |
| title | Morbidity and Mortality Among Very-low-birth-weight Infants Born to Mothers with Clinical Chorioamnionitis |
| title_full | Morbidity and Mortality Among Very-low-birth-weight Infants Born to Mothers with Clinical Chorioamnionitis |
| title_fullStr | Morbidity and Mortality Among Very-low-birth-weight Infants Born to Mothers with Clinical Chorioamnionitis |
| title_full_unstemmed | Morbidity and Mortality Among Very-low-birth-weight Infants Born to Mothers with Clinical Chorioamnionitis |
| title_short | Morbidity and Mortality Among Very-low-birth-weight Infants Born to Mothers with Clinical Chorioamnionitis |
| title_sort | morbidity and mortality among very low birth weight infants born to mothers with clinical chorioamnionitis |
| topic | clinical chorioamnionitis early-onset neonatal sepsis mortality newborn outcome periventricular leukomalacia |
| url | http://www.sciencedirect.com/science/article/pii/S1875957214000370 |
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