Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines

Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines

IntroductionColorectal cancer (CRC) is characterized by an extremely high mortality rate, mainly caused by the high metastatic potential of this type of cancer. To date, chemotherapy remains the backbone of the treatment of metastatic colorectal cancer. Three main chemotherapeutic drugs used for the...

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Main Authors: Alexandra Razumovskaya, Mariia Silkina, Andrey Poloznikov, Timur Kulagin, Maria Raigorodskaya, Nina Gorban, Anna Kudryavtseva, Maria Fedorova, Boris Alekseev, Alexander Tonevitsky, Sergey Nikulin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
colorectal cancer
organoids
chemotherapy
drug resistance
response prediction
transcriptomic gene signature
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1531175/full
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