Irisin regulates cardiac myocyte energy metabolic remodeling involved the ADRA1A-AMPK signaling pathwayng pathway

Irisin regulates cardiac myocyte energy metabolic remodeling involved the ADRA1A-AMPK signaling pathwayng pathway

Abstract Background In this study, we established a hypoxia-induced cardiac cell injury model using HL-1 cardiomyocytes and investigated the effects of Irisin intervention on the preventive and therapeutic effects of Irisin on chronic heart failure (CHF), and the underlying mechanisms in a murine mo...

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Bibliographic Details
Main Authors: Han Zhe, Jing Li, Yuan Bei, Feng Gao, Qingliang Chen
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
Chronic heart failure
Irisin
ADRA1A
AMPK
HL-1
Online Access:https://doi.org/10.1186/s40001-025-02882-z
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