Lupus Nephritis in a Patient with Sickle Cell Disease
Introduction. The diagnosis of systemic lupus erythematosus (SLE) in patients with sickle cell disease (SCD) can be difficult to establish because the musculoskeletal, central nervous system, and renal manifestations are similar in both diseases. In the presented case, we highlight the diagnostic ch...
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| Format: | Article |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/907950 |
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| author | Vinay Minocha Fauzia Rana |
| author_facet | Vinay Minocha Fauzia Rana |
| author_sort | Vinay Minocha |
| collection | DOAJ |
| description | Introduction. The diagnosis of systemic lupus erythematosus (SLE) in patients with sickle cell disease (SCD) can be difficult to establish because the musculoskeletal, central nervous system, and renal manifestations are similar in both diseases. In the presented case, we highlight the diagnostic challenge that can evolve in patients with a concurrence of both diseases and we establish the importance of early recognition and treatment of lupus nephritis in patients with SCD. Case Presentation. We present a case of a 31-year-old African American female with sickle-C disease (hemoglobin SC) who was admitted to our hospital with complaints of periumbilical abdominal pain associated with intractable nausea and vomiting, abdominal distension, and worsening lower extremity edema. Urine studies revealed nephrotic range proteinuria and the immunological investigations were consistent with lupus. A renal biopsy revealed focal proliferative lupus nephritis. Conclusion. It is important to consider the presence of a coexisting autoimmune disease in a patient with sickle hemoglobinopathy who displays an atypical and multisystem presentation that is unresponsive to conventional therapies. When a significant kidney disease is present, a renal biopsy is critical in identifying the etiology of a renal abnormality in the setting of coexisting SLE and SCD. |
| format | Article |
| id | doaj-art-fd7c2cc3be414ae2bd4b3153c601cda5 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-fd7c2cc3be414ae2bd4b3153c601cda52025-08-20T03:25:26ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/907950907950Lupus Nephritis in a Patient with Sickle Cell DiseaseVinay Minocha0Fauzia Rana1Department of Internal Medicine, University of Florida College of Medicine, Jacksonville, USADepartment of Oncology, University of Florida College of Medicine, Jacksonville, USAIntroduction. The diagnosis of systemic lupus erythematosus (SLE) in patients with sickle cell disease (SCD) can be difficult to establish because the musculoskeletal, central nervous system, and renal manifestations are similar in both diseases. In the presented case, we highlight the diagnostic challenge that can evolve in patients with a concurrence of both diseases and we establish the importance of early recognition and treatment of lupus nephritis in patients with SCD. Case Presentation. We present a case of a 31-year-old African American female with sickle-C disease (hemoglobin SC) who was admitted to our hospital with complaints of periumbilical abdominal pain associated with intractable nausea and vomiting, abdominal distension, and worsening lower extremity edema. Urine studies revealed nephrotic range proteinuria and the immunological investigations were consistent with lupus. A renal biopsy revealed focal proliferative lupus nephritis. Conclusion. It is important to consider the presence of a coexisting autoimmune disease in a patient with sickle hemoglobinopathy who displays an atypical and multisystem presentation that is unresponsive to conventional therapies. When a significant kidney disease is present, a renal biopsy is critical in identifying the etiology of a renal abnormality in the setting of coexisting SLE and SCD.http://dx.doi.org/10.1155/2013/907950 |
| spellingShingle | Vinay Minocha Fauzia Rana Lupus Nephritis in a Patient with Sickle Cell Disease Case Reports in Hematology |
| title | Lupus Nephritis in a Patient with Sickle Cell Disease |
| title_full | Lupus Nephritis in a Patient with Sickle Cell Disease |
| title_fullStr | Lupus Nephritis in a Patient with Sickle Cell Disease |
| title_full_unstemmed | Lupus Nephritis in a Patient with Sickle Cell Disease |
| title_short | Lupus Nephritis in a Patient with Sickle Cell Disease |
| title_sort | lupus nephritis in a patient with sickle cell disease |
| url | http://dx.doi.org/10.1155/2013/907950 |
| work_keys_str_mv | AT vinayminocha lupusnephritisinapatientwithsicklecelldisease AT fauziarana lupusnephritisinapatientwithsicklecelldisease |