Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus
Pemphigus is a rare and life-threatening autoimmune disease that is easily ignored in children. This study aimed to attract attention to pemphigus in the paediatric population for better understanding and recognition of the clinical characteristics and management in children’s different subtypes of...
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Medical Journals Sweden
2025-03-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/42776 |
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| author | An-Wei Chen Li Liu Huan Yang Xiao-Yan Luo Juan Xiang |
| author_facet | An-Wei Chen Li Liu Huan Yang Xiao-Yan Luo Juan Xiang |
| author_sort | An-Wei Chen |
| collection | DOAJ |
| description | Pemphigus is a rare and life-threatening autoimmune disease that is easily ignored in children. This study aimed to attract attention to pemphigus in the paediatric population for better understanding and recognition of the clinical characteristics and management in children’s different subtypes of pemphigus. The case series involved a retrospective record review of 3 patients who were referred to a department of dermatology from January 2022 to January 2024. All patients experienced a delayed diagnosis, but were eventually definitively diagnosed with pemphigus vulgaris, pemphigus foliaceus, and pemphigus erythematosus, because they all have intraepidermal blisters and elevated serum antibodies against Dsg1/Dsg3. In all 3 cases, systemic corticosteroids were used in combination with or without steroid-sparing adjuvants. The patient with pemphigus vulgaris experienced a recurrence due to discontinuous treatment; the other 2 patients achieved mostly remission after treatment, with the length of follow-up ranging from 5 to 12 months. Pemphigus in children has its own clinical characteristics and similar literature concerning improved strategies for clinical assessment and treatments are reviewed and discussed.
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| format | Article |
| id | doaj-art-fd7b926599984b32a5644ad7df60fa7b |
| institution | DOAJ |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-fd7b926599984b32a5644ad7df60fa7b2025-08-20T02:58:39ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-03-0110510.2340/actadv.v105.42776Clinical Features, Diagnosis and Treatment of Different Types of Paediatric PemphigusAn-Wei Chen0Li Liu1Huan Yang2Xiao-Yan Luo3Juan Xiang4Department of Dermatology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, ChinaDepartment of Dermatology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, ChinaDepartment of Dermatology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, ChinaDepartment of Dermatology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, ChinaDepartment of Dermatology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, ChinaPemphigus is a rare and life-threatening autoimmune disease that is easily ignored in children. This study aimed to attract attention to pemphigus in the paediatric population for better understanding and recognition of the clinical characteristics and management in children’s different subtypes of pemphigus. The case series involved a retrospective record review of 3 patients who were referred to a department of dermatology from January 2022 to January 2024. All patients experienced a delayed diagnosis, but were eventually definitively diagnosed with pemphigus vulgaris, pemphigus foliaceus, and pemphigus erythematosus, because they all have intraepidermal blisters and elevated serum antibodies against Dsg1/Dsg3. In all 3 cases, systemic corticosteroids were used in combination with or without steroid-sparing adjuvants. The patient with pemphigus vulgaris experienced a recurrence due to discontinuous treatment; the other 2 patients achieved mostly remission after treatment, with the length of follow-up ranging from 5 to 12 months. Pemphigus in children has its own clinical characteristics and similar literature concerning improved strategies for clinical assessment and treatments are reviewed and discussed. https://medicaljournalssweden.se/actadv/article/view/42776Pemphigus vulgarisPemphigus foliaceusPemphigus erythematosusChildrenTreatment |
| spellingShingle | An-Wei Chen Li Liu Huan Yang Xiao-Yan Luo Juan Xiang Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus Acta Dermato-Venereologica Pemphigus vulgaris Pemphigus foliaceus Pemphigus erythematosus Children Treatment |
| title | Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus |
| title_full | Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus |
| title_fullStr | Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus |
| title_full_unstemmed | Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus |
| title_short | Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus |
| title_sort | clinical features diagnosis and treatment of different types of paediatric pemphigus |
| topic | Pemphigus vulgaris Pemphigus foliaceus Pemphigus erythematosus Children Treatment |
| url | https://medicaljournalssweden.se/actadv/article/view/42776 |
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