Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma: Relationship with Tumor Stage and Survival after Esophagectomy
Background and Aims. Esophageal adenocarcinoma (EA) is an aggressive tumor with increasing incidence in occidental countries. Several prognostic biomarkers have been proposed, including epidermal growth factor receptor (EGFR). The aim of this study was to assess whether EGFR expression predicts EA s...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/941954 |
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| author | Daniel Navarini Richard R. Gurski Carlos Augusto Madalosso Lucas Aita Luise Meurer Fernando Fornari |
| author_facet | Daniel Navarini Richard R. Gurski Carlos Augusto Madalosso Lucas Aita Luise Meurer Fernando Fornari |
| author_sort | Daniel Navarini |
| collection | DOAJ |
| description | Background and Aims. Esophageal adenocarcinoma (EA) is an aggressive tumor with increasing incidence in occidental countries. Several prognostic biomarkers have been proposed, including epidermal growth factor receptor (EGFR). The aim of this study was to assess whether EGFR expression predicts EA staging and patient survival. Methods. In this historical cohort, consecutive patients with EA managed between 2000 and 2010 were considered eligible for the study. Surgical specimens of patients treated with transhiatal esophagectomy were evaluated to establish EGFR expression and tumor differentiation. Staging was classified according with tumor-node-metastasis (TNM) system. Survival was determined according to either medical register or patient’s family contact. Results. Thirty-seven patients who underwent esophagectomy without presurgical chemotherapy or radiotherapy were studied. EGFR expression was found in 16 patients (43%). EGFR expression was more frequent as higher was the TNM (I and II=0% versus III=47% versus IV=100%; P<0.001). Average survival in months was significantly shorter in the group of patients with EGFR expression (10.5 versus 21.7; P=0.001). Conclusions. In patients with esophageal adenocarcinoma treated with transhiatal esophagectomy, EGFR expression was related to higher TNM staging and shorter survival. EGFR expression might be assumed as a prognostic marker for esophageal adenocarcinoma. |
| format | Article |
| id | doaj-art-fd7adf4dd8454254aade54f3a55d0bf7 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-fd7adf4dd8454254aade54f3a55d0bf72025-08-20T03:25:26ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/941954941954Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma: Relationship with Tumor Stage and Survival after EsophagectomyDaniel Navarini0Richard R. Gurski1Carlos Augusto Madalosso2Lucas Aita3Luise Meurer4Fernando Fornari5Programa de Pós-Graduação em Ciências Cirúrgicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), 90035003 Porto Alegre, RS, BrazilPrograma de Pós-Graduação em Ciências Cirúrgicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), 90035003 Porto Alegre, RS, BrazilPrograma de Pós-Graduação em Ciências Cirúrgicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), 90035003 Porto Alegre, RS, BrazilPrograma de Pós-Graduação em Ciências Cirúrgicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), 90035003 Porto Alegre, RS, BrazilPrograma de Pós-Graduação: Ciências em Gastroenterologia e Hepatologia, Faculdade de Medicina, UFRGS, 90035003 Porto Alegre, RS, BrazilFaculdade de Medicina, Universidade de Passo Fundo, 99010080 Passo Fundo, RS, BrazilBackground and Aims. Esophageal adenocarcinoma (EA) is an aggressive tumor with increasing incidence in occidental countries. Several prognostic biomarkers have been proposed, including epidermal growth factor receptor (EGFR). The aim of this study was to assess whether EGFR expression predicts EA staging and patient survival. Methods. In this historical cohort, consecutive patients with EA managed between 2000 and 2010 were considered eligible for the study. Surgical specimens of patients treated with transhiatal esophagectomy were evaluated to establish EGFR expression and tumor differentiation. Staging was classified according with tumor-node-metastasis (TNM) system. Survival was determined according to either medical register or patient’s family contact. Results. Thirty-seven patients who underwent esophagectomy without presurgical chemotherapy or radiotherapy were studied. EGFR expression was found in 16 patients (43%). EGFR expression was more frequent as higher was the TNM (I and II=0% versus III=47% versus IV=100%; P<0.001). Average survival in months was significantly shorter in the group of patients with EGFR expression (10.5 versus 21.7; P=0.001). Conclusions. In patients with esophageal adenocarcinoma treated with transhiatal esophagectomy, EGFR expression was related to higher TNM staging and shorter survival. EGFR expression might be assumed as a prognostic marker for esophageal adenocarcinoma.http://dx.doi.org/10.1155/2012/941954 |
| spellingShingle | Daniel Navarini Richard R. Gurski Carlos Augusto Madalosso Lucas Aita Luise Meurer Fernando Fornari Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma: Relationship with Tumor Stage and Survival after Esophagectomy Gastroenterology Research and Practice |
| title | Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma: Relationship with Tumor Stage and Survival after Esophagectomy |
| title_full | Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma: Relationship with Tumor Stage and Survival after Esophagectomy |
| title_fullStr | Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma: Relationship with Tumor Stage and Survival after Esophagectomy |
| title_full_unstemmed | Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma: Relationship with Tumor Stage and Survival after Esophagectomy |
| title_short | Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma: Relationship with Tumor Stage and Survival after Esophagectomy |
| title_sort | epidermal growth factor receptor expression in esophageal adenocarcinoma relationship with tumor stage and survival after esophagectomy |
| url | http://dx.doi.org/10.1155/2012/941954 |
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