Efficacy of cyclin-dependent kinases 4 and 6 inhibitors in the treatment of HR +/HER2 − advanced breast cancer: a meta-analysis

Efficacy of cyclin-dependent kinases 4 and 6 inhibitors in the treatment of HR +/HER2 − advanced breast cancer: a meta-analysis

Abstract Aim This study investigates the efficacy and safety of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy (ET) in treating hormone receptor-positive (HR +), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer. Methods A systematic r...

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Bibliographic Details
Main Authors: Isah Adamu Danbala, Xu Wang, Yuting Su, Haowen Tang, Wanying Sheng, Zakari Shaibu, Iliyasu Isah, Xiao Yuan
Format: Article
Language:English
Published: BMC 2025-06-01
Series:European Journal of Medical Research
Subjects:
Breast neoplasm
Cyclin-dependent kinases 4 and 6 inhibitors
Hormone
Therapy
Meta-analysis
Online Access:https://doi.org/10.1186/s40001-025-02806-x
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