The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys
Exposure of renal tubular epithelial cells (RTCs) to kidney stones or calcium oxide crystals triggers the production of reactive oxygen species (ROS), leading to oxidative stress. This oxidative milieu incites cellular injury and elicits an inflammatory cascade within the RTCs. Notably, the cellular...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540075/full |
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| author | XiaoLong Ying XiaoLong Ying XiaoLong Ying Yang Chen Yang Chen Yang Chen ZongYao Hao ZongYao Hao ZongYao Hao HaoRan Liu HaoRan Liu HaoRan Liu |
| author_facet | XiaoLong Ying XiaoLong Ying XiaoLong Ying Yang Chen Yang Chen Yang Chen ZongYao Hao ZongYao Hao ZongYao Hao HaoRan Liu HaoRan Liu HaoRan Liu |
| author_sort | XiaoLong Ying |
| collection | DOAJ |
| description | Exposure of renal tubular epithelial cells (RTCs) to kidney stones or calcium oxide crystals triggers the production of reactive oxygen species (ROS), leading to oxidative stress. This oxidative milieu incites cellular injury and elicits an inflammatory cascade within the RTCs. Notably, the cellular membranes of the compromised cells facilitate the adherence and subsequent retention of crystals, which is instrumental in the pathogenesis of kidney stones. The pathways of ROS production are diverse, involving numerous signaling cascades. Recent researchers’ endeavors have elucidated that selective antioxidants can attenuate intracellular ROS concentrations by modulating these intricate signaling cascades. This reduction in ROS levels has been empirically demonstrated to significantly curtail the accumulation of calcium oxalate crystals within renal tissues in animal models, heralding a novel therapeutic paradigm for the amelioration of nephrolithiasis. In this review, we endeavor to elucidate the contributory role of ROS in kidney stone and explore the protective mechanisms by which certain antioxidants safeguard renal function. |
| format | Article |
| id | doaj-art-fd65b2594f724b87a87b9f245eaa0b00 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-fd65b2594f724b87a87b9f245eaa0b002025-08-20T01:55:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15400751540075The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneysXiaoLong Ying0XiaoLong Ying1XiaoLong Ying2Yang Chen3Yang Chen4Yang Chen5ZongYao Hao6ZongYao Hao7ZongYao Hao8HaoRan Liu9HaoRan Liu10HaoRan Liu11Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, Anhui, ChinaExposure of renal tubular epithelial cells (RTCs) to kidney stones or calcium oxide crystals triggers the production of reactive oxygen species (ROS), leading to oxidative stress. This oxidative milieu incites cellular injury and elicits an inflammatory cascade within the RTCs. Notably, the cellular membranes of the compromised cells facilitate the adherence and subsequent retention of crystals, which is instrumental in the pathogenesis of kidney stones. The pathways of ROS production are diverse, involving numerous signaling cascades. Recent researchers’ endeavors have elucidated that selective antioxidants can attenuate intracellular ROS concentrations by modulating these intricate signaling cascades. This reduction in ROS levels has been empirically demonstrated to significantly curtail the accumulation of calcium oxalate crystals within renal tissues in animal models, heralding a novel therapeutic paradigm for the amelioration of nephrolithiasis. In this review, we endeavor to elucidate the contributory role of ROS in kidney stone and explore the protective mechanisms by which certain antioxidants safeguard renal function.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540075/fullkidney stonesreactive oxygen speciesantioxidantsoxidative stressrenal |
| spellingShingle | XiaoLong Ying XiaoLong Ying XiaoLong Ying Yang Chen Yang Chen Yang Chen ZongYao Hao ZongYao Hao ZongYao Hao HaoRan Liu HaoRan Liu HaoRan Liu The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys Frontiers in Immunology kidney stones reactive oxygen species antioxidants oxidative stress renal |
| title | The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys |
| title_full | The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys |
| title_fullStr | The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys |
| title_full_unstemmed | The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys |
| title_short | The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys |
| title_sort | significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys |
| topic | kidney stones reactive oxygen species antioxidants oxidative stress renal |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540075/full |
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