Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic Malignancy

Noncaseating granulomas are seen surrounding tumors with varying frequency, possibly as part of an immune response to tumor cells. However, data about the association of sarcoid with gynecologic malignancy is sparse. We performed a search of our institutional database for all EBUS-TBNA biopsies cond...

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Main Authors: Bilal H. Lashari, Megumi Asai, Gissele Randleman, Martha Sack, Rajeshkumar Patel
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Pulmonary Medicine
Online Access:http://dx.doi.org/10.1155/2018/5141575
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author Bilal H. Lashari
Megumi Asai
Gissele Randleman
Martha Sack
Rajeshkumar Patel
author_facet Bilal H. Lashari
Megumi Asai
Gissele Randleman
Martha Sack
Rajeshkumar Patel
author_sort Bilal H. Lashari
collection DOAJ
description Noncaseating granulomas are seen surrounding tumors with varying frequency, possibly as part of an immune response to tumor cells. However, data about the association of sarcoid with gynecologic malignancy is sparse. We performed a search of our institutional database for all EBUS-TBNA biopsies conducted within the past five years that revealed granulomatous inflammation. All adult female patients with a history of gynecologic malignancy were included. Patients with a history of sarcoidosis or fungal or mycobacterial infection were excluded. All patients with evidence of malignant cells on TBNA specimen were excluded. Our results revealed 65 patients with histologic diagnosis of a noncaseating granuloma on EBUS-TBNA. Five patients (7.69%) had a history of gynecologic malignancy. Two patients had evidence of PET-positive nodes on surveillance scans, which led directly to the examination. Our findings suggest that distant malignancies may cause granulomatous lymphadenitis, through yet undefined mechanisms. As such, patients with evidence of mediastinal lymphadenopathy could benefit from routine sampling and histologic examination to define the pathology in the correct clinical context.
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institution Kabale University
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publishDate 2018-01-01
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series Pulmonary Medicine
spelling doaj-art-fd60d8bae3a04f75a53377a44a026bb02025-02-03T01:09:46ZengWileyPulmonary Medicine2090-18362090-18442018-01-01201810.1155/2018/51415755141575Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic MalignancyBilal H. Lashari0Megumi Asai1Gissele Randleman2Martha Sack3Rajeshkumar Patel4Department of Internal Medicine, Abington Jefferson Health, Abington, PA, USADepartment of Surgery, Abington Jefferson Health, Abington, PA, USADepartment of Pathology, Abington Jefferson Health, Abington, PA, USADepartment of Pathology, Abington Jefferson Health, Abington, PA, USAPulmonary-Critical Care Medicine, Abington Jefferson Health, Abington, PA, USANoncaseating granulomas are seen surrounding tumors with varying frequency, possibly as part of an immune response to tumor cells. However, data about the association of sarcoid with gynecologic malignancy is sparse. We performed a search of our institutional database for all EBUS-TBNA biopsies conducted within the past five years that revealed granulomatous inflammation. All adult female patients with a history of gynecologic malignancy were included. Patients with a history of sarcoidosis or fungal or mycobacterial infection were excluded. All patients with evidence of malignant cells on TBNA specimen were excluded. Our results revealed 65 patients with histologic diagnosis of a noncaseating granuloma on EBUS-TBNA. Five patients (7.69%) had a history of gynecologic malignancy. Two patients had evidence of PET-positive nodes on surveillance scans, which led directly to the examination. Our findings suggest that distant malignancies may cause granulomatous lymphadenitis, through yet undefined mechanisms. As such, patients with evidence of mediastinal lymphadenopathy could benefit from routine sampling and histologic examination to define the pathology in the correct clinical context.http://dx.doi.org/10.1155/2018/5141575
spellingShingle Bilal H. Lashari
Megumi Asai
Gissele Randleman
Martha Sack
Rajeshkumar Patel
Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic Malignancy
Pulmonary Medicine
title Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic Malignancy
title_full Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic Malignancy
title_fullStr Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic Malignancy
title_full_unstemmed Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic Malignancy
title_short Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic Malignancy
title_sort sarcoid like mediastinal lymphadenopathy in gynecologic malignancy
url http://dx.doi.org/10.1155/2018/5141575
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AT megumiasai sarcoidlikemediastinallymphadenopathyingynecologicmalignancy
AT gisselerandleman sarcoidlikemediastinallymphadenopathyingynecologicmalignancy
AT marthasack sarcoidlikemediastinallymphadenopathyingynecologicmalignancy
AT rajeshkumarpatel sarcoidlikemediastinallymphadenopathyingynecologicmalignancy