Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients
Abstract Background Hemoglobin, albumin, lymphocyte and platelet (HALP) score is derived from the counts of hemoglobin, albumin, lymphocytes, and platelets. It serves as a valuable tool for assessing both inflammation and nutritional status in critically ill patients. However, there hasn’t been a sp...
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2025-02-01
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| Series: | Journal of Health, Population and Nutrition |
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| Online Access: | https://doi.org/10.1186/s41043-025-00759-9 |
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| author | Chong Zhang Wenjin Peng Meng Ning Weiru Liang Bin Su Tingting Guo Kun Hu Wei Su Yi Chen Yingwu Liu |
| author_facet | Chong Zhang Wenjin Peng Meng Ning Weiru Liang Bin Su Tingting Guo Kun Hu Wei Su Yi Chen Yingwu Liu |
| author_sort | Chong Zhang |
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| description | Abstract Background Hemoglobin, albumin, lymphocyte and platelet (HALP) score is derived from the counts of hemoglobin, albumin, lymphocytes, and platelets. It serves as a valuable tool for assessing both inflammation and nutritional status in critically ill patients. However, there hasn’t been a specific study exploring the role of the HALP score in critically ill patients. Additionally, whether the HALP score exhibits an incremental effect on the Sequential Organ Failure Assessment (SOFA) score remains unknown. Methods In this study, we used the Medical Information Mart for Intensive Care (MIMIC-IV) version 2.2 database to evaluate the predictive value of HALP score for critically ill patients. The primary outcome investigated was intensive care unit (ICU) death, and the secondary outcomes included in-hospital mortality, ICU length of stay (LOS), hospital LOS, and 28-day mortality. Results We analyzed 20,083 critically ill patients. In logistic regression, a low HALP score (HALP score < 3.56) showed higher risk of ICU death (adjusted odds ratio: 1.41, 95% confidence interval [CI]: 1.25 to 1.59). Additionally, the HALP score improved the predictive ability of the SOFA score (∆Area under curve: 0.009, p < 0.001). In Cox proportional hazards models, a low HALP score (HALP score < 3.2) was also associated with a higher risk of 28-day mortality (adjusted hazard ratio: 1.52, 95% CI: 1.33 to 1.74). Conclusion HALP score is associated with short-term mortality. Additionally, HALP score showed an incremental effect on SOFA score in predicting short-term mortality. |
| format | Article |
| id | doaj-art-fd592d36e35445eebb6516a1b627e883 |
| institution | Kabale University |
| issn | 2072-1315 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Health, Population and Nutrition |
| spelling | doaj-art-fd592d36e35445eebb6516a1b627e8832025-02-09T12:42:58ZengBMCJournal of Health, Population and Nutrition2072-13152025-02-014411810.1186/s41043-025-00759-9Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patientsChong Zhang0Wenjin Peng1Meng Ning2Weiru Liang3Bin Su4Tingting Guo5Kun Hu6Wei Su7Yi Chen8Yingwu Liu9The Third Central Clinical College of Tianjin Medical UniversityThe Third Central Clinical College of Tianjin Medical UniversityThe Third Central Clinical College of Tianjin Medical UniversityState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeThe Third Central Clinical College of Tianjin Medical UniversityThe Third Central Clinical College of Tianjin Medical UniversityThe Third Central Clinical College of Tianjin Medical UniversityThe Third Central Clinical College of Tianjin Medical UniversityThe Third Central Clinical College of Tianjin Medical UniversityThe Third Central Clinical College of Tianjin Medical UniversityAbstract Background Hemoglobin, albumin, lymphocyte and platelet (HALP) score is derived from the counts of hemoglobin, albumin, lymphocytes, and platelets. It serves as a valuable tool for assessing both inflammation and nutritional status in critically ill patients. However, there hasn’t been a specific study exploring the role of the HALP score in critically ill patients. Additionally, whether the HALP score exhibits an incremental effect on the Sequential Organ Failure Assessment (SOFA) score remains unknown. Methods In this study, we used the Medical Information Mart for Intensive Care (MIMIC-IV) version 2.2 database to evaluate the predictive value of HALP score for critically ill patients. The primary outcome investigated was intensive care unit (ICU) death, and the secondary outcomes included in-hospital mortality, ICU length of stay (LOS), hospital LOS, and 28-day mortality. Results We analyzed 20,083 critically ill patients. In logistic regression, a low HALP score (HALP score < 3.56) showed higher risk of ICU death (adjusted odds ratio: 1.41, 95% confidence interval [CI]: 1.25 to 1.59). Additionally, the HALP score improved the predictive ability of the SOFA score (∆Area under curve: 0.009, p < 0.001). In Cox proportional hazards models, a low HALP score (HALP score < 3.2) was also associated with a higher risk of 28-day mortality (adjusted hazard ratio: 1.52, 95% CI: 1.33 to 1.74). Conclusion HALP score is associated with short-term mortality. Additionally, HALP score showed an incremental effect on SOFA score in predicting short-term mortality.https://doi.org/10.1186/s41043-025-00759-9Hemoglobin, albumin, lymphocyte and platelet scorePrognostic nutritional indexSequential organ failure assessment scoreShort-term mortality |
| spellingShingle | Chong Zhang Wenjin Peng Meng Ning Weiru Liang Bin Su Tingting Guo Kun Hu Wei Su Yi Chen Yingwu Liu Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients Journal of Health, Population and Nutrition Hemoglobin, albumin, lymphocyte and platelet score Prognostic nutritional index Sequential organ failure assessment score Short-term mortality |
| title | Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients |
| title_full | Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients |
| title_fullStr | Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients |
| title_full_unstemmed | Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients |
| title_short | Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients |
| title_sort | correlation between hemoglobin albumin lymphocyte and platelet score and short term mortality in critically ill patients |
| topic | Hemoglobin, albumin, lymphocyte and platelet score Prognostic nutritional index Sequential organ failure assessment score Short-term mortality |
| url | https://doi.org/10.1186/s41043-025-00759-9 |
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