Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro
Abstract Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1–34 were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (L...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-05-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | https://doi.org/10.1007/s13659-025-00516-9 |
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| author | Zi-Jiao Wang Bang-Yin Tan Yun Zhao Chang-Bin Wang Yun-Li Zhao Xiao-Dong Luo |
| author_facet | Zi-Jiao Wang Bang-Yin Tan Yun Zhao Chang-Bin Wang Yun-Li Zhao Xiao-Dong Luo |
| author_sort | Zi-Jiao Wang |
| collection | DOAJ |
| description | Abstract Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1–34 were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (LPS)-induced MH7A cells inflammatory model. As a result, compounds 1– 3, 6, 8, 10, 14, 17–19, 29 and 31 inhibited the activity of lactate dehydrogenase (LDH) and nitric oxide (NO) at concentrations 20 μM. Among them, compound 1 showed the best effectiveness, with inhibition rates of 46.7% for NO and 32.8% for LDH. Graphical Abstract |
| format | Article |
| id | doaj-art-fd508e51352b4b8796f2fccfa2539fed |
| institution | DOAJ |
| issn | 2192-2195 2192-2209 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj-art-fd508e51352b4b8796f2fccfa2539fed2025-08-20T03:16:47ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092025-05-011511810.1007/s13659-025-00516-9Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitroZi-Jiao Wang0Bang-Yin Tan1Yun Zhao2Chang-Bin Wang3Yun-Li Zhao4Xiao-Dong Luo5State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesYunnan Characteristic Plant Extraction Laboratory Co. Ltd, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Southwest United Graduate SchoolState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesAbstract Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1–34 were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (LPS)-induced MH7A cells inflammatory model. As a result, compounds 1– 3, 6, 8, 10, 14, 17–19, 29 and 31 inhibited the activity of lactate dehydrogenase (LDH) and nitric oxide (NO) at concentrations 20 μM. Among them, compound 1 showed the best effectiveness, with inhibition rates of 46.7% for NO and 32.8% for LDH. Graphical Abstracthttps://doi.org/10.1007/s13659-025-00516-9Lycium barbarum leavesChemical constituentsAnti-rheumatoid arthritis |
| spellingShingle | Zi-Jiao Wang Bang-Yin Tan Yun Zhao Chang-Bin Wang Yun-Li Zhao Xiao-Dong Luo Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro Natural Products and Bioprospecting Lycium barbarum leaves Chemical constituents Anti-rheumatoid arthritis |
| title | Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro |
| title_full | Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro |
| title_fullStr | Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro |
| title_full_unstemmed | Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro |
| title_short | Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro |
| title_sort | chemical constituents of lycium barbarum leaves and their anti rheumatoid arthritis activity in vitro |
| topic | Lycium barbarum leaves Chemical constituents Anti-rheumatoid arthritis |
| url | https://doi.org/10.1007/s13659-025-00516-9 |
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