Primary Angiosarcoma of the Spleen: Rare Diagnosis with Atypical Clinical Course
Primary angiosarcoma of the spleen is a rare diagnosis with poor prognosis. Morphologically, it demonstrates conventional blood vessel differentiation. We present a case of 65-year-old female who underwent radical splenectomy for primary angiosarcoma of the spleen. After three-year disease-free inte...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/4905726 |
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| author | Filip Kohutek Ladislav Badik Branislav Bystricky |
| author_facet | Filip Kohutek Ladislav Badik Branislav Bystricky |
| author_sort | Filip Kohutek |
| collection | DOAJ |
| description | Primary angiosarcoma of the spleen is a rare diagnosis with poor prognosis. Morphologically, it demonstrates conventional blood vessel differentiation. We present a case of 65-year-old female who underwent radical splenectomy for primary angiosarcoma of the spleen. After three-year disease-free interval, she was diagnosed with bone-only metastatic disease. Palliative radiotherapy and bisphosphonates kept her disease reasonably stable for another four years. After development of lung metastases, six cycles of single agent doxorubicin kept her progression-free for six years. Upon further progression in lungs, thirteen years after original diagnosis, lung biopsy confirmed metastatic splenic angiosarcoma in the lungs. She started weekly paclitaxel chemotherapy. Although splenic angiosarcoma generally carries grave prognosis, some patients may enjoy prolonged periods of disease stabilization. Durable benefit can be achieved in some patients with multimodality management. We review the literature focusing on systemic treatment for this rare tumor. |
| format | Article |
| id | doaj-art-fd4ba527fbb04e1a9ff7585bae427690 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-fd4ba527fbb04e1a9ff7585bae4276902025-08-20T03:25:26ZengWileyCase Reports in Oncological Medicine2090-67062090-67142016-01-01201610.1155/2016/49057264905726Primary Angiosarcoma of the Spleen: Rare Diagnosis with Atypical Clinical CourseFilip Kohutek0Ladislav Badik1Branislav Bystricky2Department of Oncology, Faculty Hospital Trencin, Trencin, SlovakiaDepartment of Radiology, Faculty Hospital Trencin, Trencin, SlovakiaDepartment of Oncology, Faculty Hospital Trencin, Trencin, SlovakiaPrimary angiosarcoma of the spleen is a rare diagnosis with poor prognosis. Morphologically, it demonstrates conventional blood vessel differentiation. We present a case of 65-year-old female who underwent radical splenectomy for primary angiosarcoma of the spleen. After three-year disease-free interval, she was diagnosed with bone-only metastatic disease. Palliative radiotherapy and bisphosphonates kept her disease reasonably stable for another four years. After development of lung metastases, six cycles of single agent doxorubicin kept her progression-free for six years. Upon further progression in lungs, thirteen years after original diagnosis, lung biopsy confirmed metastatic splenic angiosarcoma in the lungs. She started weekly paclitaxel chemotherapy. Although splenic angiosarcoma generally carries grave prognosis, some patients may enjoy prolonged periods of disease stabilization. Durable benefit can be achieved in some patients with multimodality management. We review the literature focusing on systemic treatment for this rare tumor.http://dx.doi.org/10.1155/2016/4905726 |
| spellingShingle | Filip Kohutek Ladislav Badik Branislav Bystricky Primary Angiosarcoma of the Spleen: Rare Diagnosis with Atypical Clinical Course Case Reports in Oncological Medicine |
| title | Primary Angiosarcoma of the Spleen: Rare Diagnosis with Atypical Clinical Course |
| title_full | Primary Angiosarcoma of the Spleen: Rare Diagnosis with Atypical Clinical Course |
| title_fullStr | Primary Angiosarcoma of the Spleen: Rare Diagnosis with Atypical Clinical Course |
| title_full_unstemmed | Primary Angiosarcoma of the Spleen: Rare Diagnosis with Atypical Clinical Course |
| title_short | Primary Angiosarcoma of the Spleen: Rare Diagnosis with Atypical Clinical Course |
| title_sort | primary angiosarcoma of the spleen rare diagnosis with atypical clinical course |
| url | http://dx.doi.org/10.1155/2016/4905726 |
| work_keys_str_mv | AT filipkohutek primaryangiosarcomaofthespleenrarediagnosiswithatypicalclinicalcourse AT ladislavbadik primaryangiosarcomaofthespleenrarediagnosiswithatypicalclinicalcourse AT branislavbystricky primaryangiosarcomaofthespleenrarediagnosiswithatypicalclinicalcourse |