Study on the mechanism of no. 8 burn ointment in burn treatment based on network pharmacology and experimental verification
IntroductionAs a traditional Chinese compound formulation, No.8 burn ointment has demonstrated notable efficacy over half a century of clinical use, particularly in facilitating the healing of burn wounds.MethodsThis study integrates clinical data, liquid chromatography-mass spectrometry, network ph...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1511741/full |
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| author | Le Qiu Danlei Xing Yuanqiang Zhu Zhiwei Zhuang Yexiang Sun Peng Gong Xulin Chen |
| author_facet | Le Qiu Danlei Xing Yuanqiang Zhu Zhiwei Zhuang Yexiang Sun Peng Gong Xulin Chen |
| author_sort | Le Qiu |
| collection | DOAJ |
| description | IntroductionAs a traditional Chinese compound formulation, No.8 burn ointment has demonstrated notable efficacy over half a century of clinical use, particularly in facilitating the healing of burn wounds.MethodsThis study integrates clinical data, liquid chromatography-mass spectrometry, network pharmacology and experimental validation to elucidate the mechanisms by which No.8 burn ointment promotes burn wound healing and to identify its key active components.ResultsThe findings reveal that the ointment may accelerate wound repair by modulating the HIF-1 signaling pathway. The network pharmacology analysis has identified HIF-1α as a core target of the No.8 burn ointment’s action and has identified the key active molecules β-Elemonic acid and Rubiadin, which interact with the HIF-1α protein and influence the HIF-1 pathway.ConclusionThis research not only provides a theoretical foundation for the selection of targeted drugs in burn treatment and the optimization of traditional Chinese compounds but also provides new ideas for future research in related fields. |
| format | Article |
| id | doaj-art-fd49b67989714f2caf5589fc918e3f01 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-fd49b67989714f2caf5589fc918e3f012025-08-20T03:51:19ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.15117411511741Study on the mechanism of no. 8 burn ointment in burn treatment based on network pharmacology and experimental verificationLe Qiu0Danlei Xing1Yuanqiang Zhu2Zhiwei Zhuang3Yexiang Sun4Peng Gong5Xulin Chen6Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaIntroductionAs a traditional Chinese compound formulation, No.8 burn ointment has demonstrated notable efficacy over half a century of clinical use, particularly in facilitating the healing of burn wounds.MethodsThis study integrates clinical data, liquid chromatography-mass spectrometry, network pharmacology and experimental validation to elucidate the mechanisms by which No.8 burn ointment promotes burn wound healing and to identify its key active components.ResultsThe findings reveal that the ointment may accelerate wound repair by modulating the HIF-1 signaling pathway. The network pharmacology analysis has identified HIF-1α as a core target of the No.8 burn ointment’s action and has identified the key active molecules β-Elemonic acid and Rubiadin, which interact with the HIF-1α protein and influence the HIF-1 pathway.ConclusionThis research not only provides a theoretical foundation for the selection of targeted drugs in burn treatment and the optimization of traditional Chinese compounds but also provides new ideas for future research in related fields.https://www.frontiersin.org/articles/10.3389/fphar.2025.1511741/fullNo.8 burn ointmentnetwork pharmacologyburnHIF-1αmolecular docking |
| spellingShingle | Le Qiu Danlei Xing Yuanqiang Zhu Zhiwei Zhuang Yexiang Sun Peng Gong Xulin Chen Study on the mechanism of no. 8 burn ointment in burn treatment based on network pharmacology and experimental verification Frontiers in Pharmacology No.8 burn ointment network pharmacology burn HIF-1α molecular docking |
| title | Study on the mechanism of no. 8 burn ointment in burn treatment based on network pharmacology and experimental verification |
| title_full | Study on the mechanism of no. 8 burn ointment in burn treatment based on network pharmacology and experimental verification |
| title_fullStr | Study on the mechanism of no. 8 burn ointment in burn treatment based on network pharmacology and experimental verification |
| title_full_unstemmed | Study on the mechanism of no. 8 burn ointment in burn treatment based on network pharmacology and experimental verification |
| title_short | Study on the mechanism of no. 8 burn ointment in burn treatment based on network pharmacology and experimental verification |
| title_sort | study on the mechanism of no 8 burn ointment in burn treatment based on network pharmacology and experimental verification |
| topic | No.8 burn ointment network pharmacology burn HIF-1α molecular docking |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1511741/full |
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