A Network-Based Approach to Explore the Mechanism and Bioactive Compounds of Erzhi Pill against Metabolic Dysfunction-Associated Fatty Liver Disease
Erzhi pill (EZP), a classical traditional Chinese medicine prescription, exerts a potent hepatoprotective effect against metabolic dysfunction-associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD). However, the mechanism and bioactive compounds underlyi...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/7867245 |
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| author | Shaojie Huang Fei Mu Fei Li Wenjun Wang Haixia Chen Lu Lei Yang Ma Yi Ding Jingwen Wang |
| author_facet | Shaojie Huang Fei Mu Fei Li Wenjun Wang Haixia Chen Lu Lei Yang Ma Yi Ding Jingwen Wang |
| author_sort | Shaojie Huang |
| collection | DOAJ |
| description | Erzhi pill (EZP), a classical traditional Chinese medicine prescription, exerts a potent hepatoprotective effect against metabolic dysfunction-associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD). However, the mechanism and bioactive compounds underlying the hepatoprotective effect of EZP have not been fully elucidated. In this study, a systematic analytical platform was built to explore the mechanism and bioactive compounds of EZP against MAFLD. This was carried out through target prediction, protein-protein interaction (PPI) network construction, gene ontology, KEGG pathway enrichment, and molecular docking. According to the topological parameters of the PPI network, compound-target-pathway network, 9 targets, and 11 bioactive compounds were identified as core targets and bioactive compounds for molecular docking. The results showed that EZP exerts anti-MAFLD effects through a multicomponent, multitarget, multipathway manner, and luteolin and linarin may be the bioactive compounds of EZP. This study provides further research insights and helps explore the hepatoprotective mechanism of EZP. |
| format | Article |
| id | doaj-art-fd444d2db9e04c8b8d3dca0fd1c1c21e |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-fd444d2db9e04c8b8d3dca0fd1c1c21e2025-02-03T01:05:04ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/78672457867245A Network-Based Approach to Explore the Mechanism and Bioactive Compounds of Erzhi Pill against Metabolic Dysfunction-Associated Fatty Liver DiseaseShaojie Huang0Fei Mu1Fei Li2Wenjun Wang3Haixia Chen4Lu Lei5Yang Ma6Yi Ding7Jingwen Wang8Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, ChinaErzhi pill (EZP), a classical traditional Chinese medicine prescription, exerts a potent hepatoprotective effect against metabolic dysfunction-associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD). However, the mechanism and bioactive compounds underlying the hepatoprotective effect of EZP have not been fully elucidated. In this study, a systematic analytical platform was built to explore the mechanism and bioactive compounds of EZP against MAFLD. This was carried out through target prediction, protein-protein interaction (PPI) network construction, gene ontology, KEGG pathway enrichment, and molecular docking. According to the topological parameters of the PPI network, compound-target-pathway network, 9 targets, and 11 bioactive compounds were identified as core targets and bioactive compounds for molecular docking. The results showed that EZP exerts anti-MAFLD effects through a multicomponent, multitarget, multipathway manner, and luteolin and linarin may be the bioactive compounds of EZP. This study provides further research insights and helps explore the hepatoprotective mechanism of EZP.http://dx.doi.org/10.1155/2020/7867245 |
| spellingShingle | Shaojie Huang Fei Mu Fei Li Wenjun Wang Haixia Chen Lu Lei Yang Ma Yi Ding Jingwen Wang A Network-Based Approach to Explore the Mechanism and Bioactive Compounds of Erzhi Pill against Metabolic Dysfunction-Associated Fatty Liver Disease Journal of Diabetes Research |
| title | A Network-Based Approach to Explore the Mechanism and Bioactive Compounds of Erzhi Pill against Metabolic Dysfunction-Associated Fatty Liver Disease |
| title_full | A Network-Based Approach to Explore the Mechanism and Bioactive Compounds of Erzhi Pill against Metabolic Dysfunction-Associated Fatty Liver Disease |
| title_fullStr | A Network-Based Approach to Explore the Mechanism and Bioactive Compounds of Erzhi Pill against Metabolic Dysfunction-Associated Fatty Liver Disease |
| title_full_unstemmed | A Network-Based Approach to Explore the Mechanism and Bioactive Compounds of Erzhi Pill against Metabolic Dysfunction-Associated Fatty Liver Disease |
| title_short | A Network-Based Approach to Explore the Mechanism and Bioactive Compounds of Erzhi Pill against Metabolic Dysfunction-Associated Fatty Liver Disease |
| title_sort | network based approach to explore the mechanism and bioactive compounds of erzhi pill against metabolic dysfunction associated fatty liver disease |
| url | http://dx.doi.org/10.1155/2020/7867245 |
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