A novel adjuvant system BK-02 with CpG2006 and MF59 enhances the immunogenicity of a herpes zoster subunit vaccine

A novel adjuvant system BK-02 with CpG2006 and MF59 enhances the immunogenicity of a herpes zoster subunit vaccine

IntroductionReactivation of the varicella-zoster virus (VZV) results in herpes zoster (HZ), which can lead to complications such as postherpetic neuralgia. The commercially available HZ subunit adjuvanted vaccine, Shingrix®, offers significant protection against HZ in older adults. However, the adju...

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Bibliographic Details
Main Authors: Zihan Wang, Yingnan Guo, Xin Tang, Ying Sun, Tingting Wu, Hanyu Peng, Cenrong Wang, Weiheng Su, Chunlai Jiang, Yang Zang, Yaru Quan, Kangwei Xu, Bo Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
herpes zoster vaccine
glycoprotein E
adjuvant system
CpG ODN
MF59
cellular immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1641109/full
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