Protein kinase C theta is required for efficient induction of IL-10-secreting T cells.

Protein kinase C theta is required for efficient induction of IL-10-secreting T cells.

Secretion of interleukin-10 (IL-10) by CD4+ T cells is an essential immunoregulatory mechanism. The work presented here assesses the role of the signaling molecule protein kinase C theta (PKCθ) in the induction of IL-10 expression in CD4+ T cells. Using wildtype and PKCθ-deficient Tg4 T cell recepto...

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Bibliographic Details
Main Authors: Graham J Britton, Ruth E Mitchell, Bronwen R Burton, David C Wraith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171547&type=printable
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