Categories, applications, and potential of stem cells in bone regeneration: an overview
Bone defects affect many individuals globally and can result in significant suffering and impairment, particularly among the elderly population. In addition, current treatment options for critical-size bone defects, such as autologous or allogeneic bone graft transplantation, present significant cha...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1606100/full |
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| author | Mingyang Jiao Ting Shuai Zhongfang Zhao Yuwei Wu Linwei Yu Jingwen Sun Raffaele De Caro Veronica Macchi Andrea Porzionato Elena Stocco Elena Stocco Elena Stocco Chanyuan Jin |
| author_facet | Mingyang Jiao Ting Shuai Zhongfang Zhao Yuwei Wu Linwei Yu Jingwen Sun Raffaele De Caro Veronica Macchi Andrea Porzionato Elena Stocco Elena Stocco Elena Stocco Chanyuan Jin |
| author_sort | Mingyang Jiao |
| collection | DOAJ |
| description | Bone defects affect many individuals globally and can result in significant suffering and impairment, particularly among the elderly population. In addition, current treatment options for critical-size bone defects, such as autologous or allogeneic bone graft transplantation, present significant challenges. Within this clinical scenario the identification of novel and effective approaches for bone regeneration is urgently needed, and options derived from tissue engineering may be particularly appealing. Bone tissue engineering for bone regeneration involves the application of seed cells, growth factors, and biomaterials to create bioactive substitutes for repairing bone defects. In recent decades, advancements in stem cell research and biological biomaterials have led to remarkable breakthroughs in the field of bone regeneration. In particular, various categories of stem cells have been isolated, characterized, and employed in tissue engineering approaches. This review summarizes the applications of the main types of stem cells currently used for bone regeneration through tissue engineering approaches, and it also pays attention to the most appealing materials for it. |
| format | Article |
| id | doaj-art-fd3e5cea2d5a44c49dcc13813fbde47f |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-fd3e5cea2d5a44c49dcc13813fbde47f2025-08-20T15:25:39ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-08-011210.3389/fmed.2025.16061001606100Categories, applications, and potential of stem cells in bone regeneration: an overviewMingyang Jiao0Ting Shuai1Zhongfang Zhao2Yuwei Wu3Linwei Yu4Jingwen Sun5Raffaele De Caro6Veronica Macchi7Andrea Porzionato8Elena Stocco9Elena Stocco10Elena Stocco11Chanyuan Jin12Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Department of Prosthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, ChinaThe Second Clinical Division of Peking University School and Hospital of Stomatology, Beijing, ChinaHospital of Stomatology, Lanzhou University, Lanzhou, ChinaThe Second Clinical Division of Peking University School and Hospital of Stomatology, Beijing, ChinaBeijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Department of Prosthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaSection of Human Anatomy, Department of Neuroscience, University of Padova, Padua, ItalySection of Human Anatomy, Department of Neuroscience, University of Padova, Padua, ItalySection of Human Anatomy, Department of Neuroscience, University of Padova, Padua, ItalySection of Human Anatomy, Department of Neuroscience, University of Padova, Padua, ItalyDepartment of Women’s and Children’s Health, University of Padova, Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padua, ItalyThe Second Clinical Division of Peking University School and Hospital of Stomatology, Beijing, ChinaBone defects affect many individuals globally and can result in significant suffering and impairment, particularly among the elderly population. In addition, current treatment options for critical-size bone defects, such as autologous or allogeneic bone graft transplantation, present significant challenges. Within this clinical scenario the identification of novel and effective approaches for bone regeneration is urgently needed, and options derived from tissue engineering may be particularly appealing. Bone tissue engineering for bone regeneration involves the application of seed cells, growth factors, and biomaterials to create bioactive substitutes for repairing bone defects. In recent decades, advancements in stem cell research and biological biomaterials have led to remarkable breakthroughs in the field of bone regeneration. In particular, various categories of stem cells have been isolated, characterized, and employed in tissue engineering approaches. This review summarizes the applications of the main types of stem cells currently used for bone regeneration through tissue engineering approaches, and it also pays attention to the most appealing materials for it.https://www.frontiersin.org/articles/10.3389/fmed.2025.1606100/fullstem cellsbone tissue engineeringbiomaterialsbone regenerationregenerative medicineosteogenic differentiation |
| spellingShingle | Mingyang Jiao Ting Shuai Zhongfang Zhao Yuwei Wu Linwei Yu Jingwen Sun Raffaele De Caro Veronica Macchi Andrea Porzionato Elena Stocco Elena Stocco Elena Stocco Chanyuan Jin Categories, applications, and potential of stem cells in bone regeneration: an overview Frontiers in Medicine stem cells bone tissue engineering biomaterials bone regeneration regenerative medicine osteogenic differentiation |
| title | Categories, applications, and potential of stem cells in bone regeneration: an overview |
| title_full | Categories, applications, and potential of stem cells in bone regeneration: an overview |
| title_fullStr | Categories, applications, and potential of stem cells in bone regeneration: an overview |
| title_full_unstemmed | Categories, applications, and potential of stem cells in bone regeneration: an overview |
| title_short | Categories, applications, and potential of stem cells in bone regeneration: an overview |
| title_sort | categories applications and potential of stem cells in bone regeneration an overview |
| topic | stem cells bone tissue engineering biomaterials bone regeneration regenerative medicine osteogenic differentiation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1606100/full |
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