Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review
With the consistent occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the prevalence of various ocular complications has increased over time. SARS-CoV-2 infection has been shown to have neurotropism and therefore to lead to not only peripheral inflammatory respons...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1515768/full |
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| author | Yun Zhao Ying Tang Qi Yao Wang Jia Li |
| author_facet | Yun Zhao Ying Tang Qi Yao Wang Jia Li |
| author_sort | Yun Zhao |
| collection | DOAJ |
| description | With the consistent occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the prevalence of various ocular complications has increased over time. SARS-CoV-2 infection has been shown to have neurotropism and therefore to lead to not only peripheral inflammatory responses but also neuroinflammation. Because the receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), can be found in many intraocular tissues, coronavirus disease 2019 (COVID-19) may also contribute to persistent intraocular neuroinflammation, microcirculation dysfunction and ocular symptoms. Increased awareness of neuroinflammation and future research on interventional strategies for SARS-CoV-2 infection are important for improving long-term outcomes, reducing disease burden, and improving quality of life. Therefore, the aim of this review is to focus on SARS-CoV-2 infection and intraocular neuroinflammation and to discuss current evidence and future perspectives, especially possible connections between conditions and potential treatment strategies. |
| format | Article |
| id | doaj-art-fd3c64d324e444dca5f7ab5a3fad5edd |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-fd3c64d324e444dca5f7ab5a3fad5edd2025-02-04T05:28:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15157681515768Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a reviewYun ZhaoYing TangQi Yao WangJia LiWith the consistent occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the prevalence of various ocular complications has increased over time. SARS-CoV-2 infection has been shown to have neurotropism and therefore to lead to not only peripheral inflammatory responses but also neuroinflammation. Because the receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), can be found in many intraocular tissues, coronavirus disease 2019 (COVID-19) may also contribute to persistent intraocular neuroinflammation, microcirculation dysfunction and ocular symptoms. Increased awareness of neuroinflammation and future research on interventional strategies for SARS-CoV-2 infection are important for improving long-term outcomes, reducing disease burden, and improving quality of life. Therefore, the aim of this review is to focus on SARS-CoV-2 infection and intraocular neuroinflammation and to discuss current evidence and future perspectives, especially possible connections between conditions and potential treatment strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1515768/fullCOVID-19SARS-CoV-2neuroinflammationocular complicationsocular manifestations |
| spellingShingle | Yun Zhao Ying Tang Qi Yao Wang Jia Li Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review Frontiers in Immunology COVID-19 SARS-CoV-2 neuroinflammation ocular complications ocular manifestations |
| title | Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review |
| title_full | Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review |
| title_fullStr | Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review |
| title_full_unstemmed | Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review |
| title_short | Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review |
| title_sort | ocular neuroinflammatory response secondary to sars cov 2 infection a review |
| topic | COVID-19 SARS-CoV-2 neuroinflammation ocular complications ocular manifestations |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1515768/full |
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