Chinese and western medicine treatment of myocardial fibrosis drugs
Myocardial fibrosis (MF) is a common pathological manifestation of many cardiovascular diseases, such as myocardial infarction, myocardial ischemia, and sudden cardiac death. It is characterized by excessive proliferation and activation of fibroblasts, transformation into myofibroblasts, and, eventu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1477601/full |
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| author | Yuxi Zhu Yuxi Zhu Fangmei Zhang Zhongcheng Li Yu Zhou Yi Shu Jian Ruan Guo Chen |
| author_facet | Yuxi Zhu Yuxi Zhu Fangmei Zhang Zhongcheng Li Yu Zhou Yi Shu Jian Ruan Guo Chen |
| author_sort | Yuxi Zhu |
| collection | DOAJ |
| description | Myocardial fibrosis (MF) is a common pathological manifestation of many cardiovascular diseases, such as myocardial infarction, myocardial ischemia, and sudden cardiac death. It is characterized by excessive proliferation and activation of fibroblasts, transformation into myofibroblasts, and, eventually, excessive deposition of the extracellular matrix, resulting in heart damage. Currently, modern drugs such as angiotensin-converting enzyme inhibitors, diuretics, and β-blockers can improve myocardial fibrosis in clinical treatment, but their therapeutic effect on this disease is limited, with obvious side effects and high cost. Traditional Chinese medicine (TCM) has the advantages of multiple targets, low cost, and few side effects. Traditional Chinese medicines, such as Salvia miltiorrhiza, Astragalus, and Angelica extracts, and patent Chinese medicines, such as Qiliqiangxin capsules, Shenqi Yiqi dropping pills, and Tongxinluo capsules, can improve myocardial fibrosis. In this review, current Chinese and Western medicine methods for treating myocardial fibrosis are discussed. The signaling pathways and targets of Chinese and Western medicine are involved in the treatment of myocardial fibrosis. This review aimed to provide valuable insights and ideas for both clinical treatment and basic research on myocardial fibrosis. |
| format | Article |
| id | doaj-art-fd36165165b841c09e027dbc24ed7028 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-fd36165165b841c09e027dbc24ed70282025-01-15T06:10:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.14776011477601Chinese and western medicine treatment of myocardial fibrosis drugsYuxi Zhu0Yuxi Zhu1Fangmei Zhang2Zhongcheng Li3Yu Zhou4Yi Shu5Jian Ruan6Guo Chen7Department of Acupuncture, Bao’an Authentic TCM Therapy Hospital, Shenzheng, ChinaGraduate School, Jiangxi University of Chinese Medicine, Nanchang, ChinaFever Clinic, The 334 Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Acupuncture, Bao’an Authentic TCM Therapy Hospital, Shenzheng, ChinaDepartment of Acupuncture, Bao’an Authentic TCM Therapy Hospital, Shenzheng, ChinaDepartment of Acupuncture, Bao’an Authentic TCM Therapy Hospital, Shenzheng, ChinaGraduate School, Jiangxi University of Chinese Medicine, Nanchang, ChinaDepartment of Acupuncture, Bao’an Authentic TCM Therapy Hospital, Shenzheng, ChinaMyocardial fibrosis (MF) is a common pathological manifestation of many cardiovascular diseases, such as myocardial infarction, myocardial ischemia, and sudden cardiac death. It is characterized by excessive proliferation and activation of fibroblasts, transformation into myofibroblasts, and, eventually, excessive deposition of the extracellular matrix, resulting in heart damage. Currently, modern drugs such as angiotensin-converting enzyme inhibitors, diuretics, and β-blockers can improve myocardial fibrosis in clinical treatment, but their therapeutic effect on this disease is limited, with obvious side effects and high cost. Traditional Chinese medicine (TCM) has the advantages of multiple targets, low cost, and few side effects. Traditional Chinese medicines, such as Salvia miltiorrhiza, Astragalus, and Angelica extracts, and patent Chinese medicines, such as Qiliqiangxin capsules, Shenqi Yiqi dropping pills, and Tongxinluo capsules, can improve myocardial fibrosis. In this review, current Chinese and Western medicine methods for treating myocardial fibrosis are discussed. The signaling pathways and targets of Chinese and Western medicine are involved in the treatment of myocardial fibrosis. This review aimed to provide valuable insights and ideas for both clinical treatment and basic research on myocardial fibrosis.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1477601/fullmyocardial fibrosisWestern medicineChinese medicinedrugsexcessive extracellular matrix |
| spellingShingle | Yuxi Zhu Yuxi Zhu Fangmei Zhang Zhongcheng Li Yu Zhou Yi Shu Jian Ruan Guo Chen Chinese and western medicine treatment of myocardial fibrosis drugs Frontiers in Cardiovascular Medicine myocardial fibrosis Western medicine Chinese medicine drugs excessive extracellular matrix |
| title | Chinese and western medicine treatment of myocardial fibrosis drugs |
| title_full | Chinese and western medicine treatment of myocardial fibrosis drugs |
| title_fullStr | Chinese and western medicine treatment of myocardial fibrosis drugs |
| title_full_unstemmed | Chinese and western medicine treatment of myocardial fibrosis drugs |
| title_short | Chinese and western medicine treatment of myocardial fibrosis drugs |
| title_sort | chinese and western medicine treatment of myocardial fibrosis drugs |
| topic | myocardial fibrosis Western medicine Chinese medicine drugs excessive extracellular matrix |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1477601/full |
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