Protein biomarkers for bipolar II disorder are correlated with affective cognitive performance
Abstract Background In our previous research, we identified five candidate proteins—Carbonic Anhydrase 1 (CA-1), Matrix Metallopeptidase 9 (MMP9), Peroxiredoxin 2 (PRDX2), Phenylalanyl-tRNA Synthetase Subunit Beta (FARSB), and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)—as prospective biom...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-025-07104-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849238431743344640 |
|---|---|
| author | Sheng-Yu Lee Sung-Chou Li Tzu-Yun Wang Ru-Band Lu Liang-Jen Wang Kuo-Wang Tsai |
| author_facet | Sheng-Yu Lee Sung-Chou Li Tzu-Yun Wang Ru-Band Lu Liang-Jen Wang Kuo-Wang Tsai |
| author_sort | Sheng-Yu Lee |
| collection | DOAJ |
| description | Abstract Background In our previous research, we identified five candidate proteins—Carbonic Anhydrase 1 (CA-1), Matrix Metallopeptidase 9 (MMP9), Peroxiredoxin 2 (PRDX2), Phenylalanyl-tRNA Synthetase Subunit Beta (FARSB), and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)—as prospective biomarkers for bipolar II disorder (BD-II). In this study, we explored the relationships between these potential plasma proteins and cognitive performance in BD-II patients using the Brief Assessment of Cognition in Affective Disorders (BACA), a validated tool for assessing cognitive deficits in mood disorders. Methods One hundred and seventeen participants with BD-II and 41 controls participated in this study. Plasma concentrations of the aforementioned proteins were measured, and cognitive performance was evaluated using the BACA. Results Our findings indicated that the BD-II group scored significantly lower than the control group across several BACA subtests, including Digit Sequencing, Symbol Coding, Verbal Memory, and Verbal Fluency, and in overall composite scores and all subtests of the Affective Interference Test (AIT) and Emotion Inhibition Test (EIT). Notably, we observed significant correlations in the BD-II group between levels of CA-1 (r = -0.26, P = 0.005), FARSB (r = 0.399, P < 0.001), and MMP9 (r = 0.24, P = 0.008) with the AIT-Cued affective words subtest. In contrast, a significant correlation was found between the Symbol Coding task and PCSK9 levels (r = 0.35, P = 0.003) in the control group, but not in the BD-II group. Conclusion These findings offer new perspectives on the underlying mechanisms contributing to cognitive decline in individuals with BD-II. |
| format | Article |
| id | doaj-art-fd2fb6d7f79b41b8bde862d210abbb53 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-fd2fb6d7f79b41b8bde862d210abbb532025-08-20T04:01:36ZengBMCBMC Psychiatry1471-244X2025-07-0125111310.1186/s12888-025-07104-8Protein biomarkers for bipolar II disorder are correlated with affective cognitive performanceSheng-Yu Lee0Sung-Chou Li1Tzu-Yun Wang2Ru-Band Lu3Liang-Jen Wang4Kuo-Wang Tsai5Department of Psychiatry, Kaohsiung Veterans General HospitalDepartment of Medical Education and Research, Kaohsiung Veterans General HospitalDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityDepartment of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Research, Buddhist Tzu Chi Medical Foundation, Taipei Tzu Chi HospitalAbstract Background In our previous research, we identified five candidate proteins—Carbonic Anhydrase 1 (CA-1), Matrix Metallopeptidase 9 (MMP9), Peroxiredoxin 2 (PRDX2), Phenylalanyl-tRNA Synthetase Subunit Beta (FARSB), and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)—as prospective biomarkers for bipolar II disorder (BD-II). In this study, we explored the relationships between these potential plasma proteins and cognitive performance in BD-II patients using the Brief Assessment of Cognition in Affective Disorders (BACA), a validated tool for assessing cognitive deficits in mood disorders. Methods One hundred and seventeen participants with BD-II and 41 controls participated in this study. Plasma concentrations of the aforementioned proteins were measured, and cognitive performance was evaluated using the BACA. Results Our findings indicated that the BD-II group scored significantly lower than the control group across several BACA subtests, including Digit Sequencing, Symbol Coding, Verbal Memory, and Verbal Fluency, and in overall composite scores and all subtests of the Affective Interference Test (AIT) and Emotion Inhibition Test (EIT). Notably, we observed significant correlations in the BD-II group between levels of CA-1 (r = -0.26, P = 0.005), FARSB (r = 0.399, P < 0.001), and MMP9 (r = 0.24, P = 0.008) with the AIT-Cued affective words subtest. In contrast, a significant correlation was found between the Symbol Coding task and PCSK9 levels (r = 0.35, P = 0.003) in the control group, but not in the BD-II group. Conclusion These findings offer new perspectives on the underlying mechanisms contributing to cognitive decline in individuals with BD-II.https://doi.org/10.1186/s12888-025-07104-8Bipolar II disorderProteinCognitive functionCorrelation |
| spellingShingle | Sheng-Yu Lee Sung-Chou Li Tzu-Yun Wang Ru-Band Lu Liang-Jen Wang Kuo-Wang Tsai Protein biomarkers for bipolar II disorder are correlated with affective cognitive performance BMC Psychiatry Bipolar II disorder Protein Cognitive function Correlation |
| title | Protein biomarkers for bipolar II disorder are correlated with affective cognitive performance |
| title_full | Protein biomarkers for bipolar II disorder are correlated with affective cognitive performance |
| title_fullStr | Protein biomarkers for bipolar II disorder are correlated with affective cognitive performance |
| title_full_unstemmed | Protein biomarkers for bipolar II disorder are correlated with affective cognitive performance |
| title_short | Protein biomarkers for bipolar II disorder are correlated with affective cognitive performance |
| title_sort | protein biomarkers for bipolar ii disorder are correlated with affective cognitive performance |
| topic | Bipolar II disorder Protein Cognitive function Correlation |
| url | https://doi.org/10.1186/s12888-025-07104-8 |
| work_keys_str_mv | AT shengyulee proteinbiomarkersforbipolariidisorderarecorrelatedwithaffectivecognitiveperformance AT sungchouli proteinbiomarkersforbipolariidisorderarecorrelatedwithaffectivecognitiveperformance AT tzuyunwang proteinbiomarkersforbipolariidisorderarecorrelatedwithaffectivecognitiveperformance AT rubandlu proteinbiomarkersforbipolariidisorderarecorrelatedwithaffectivecognitiveperformance AT liangjenwang proteinbiomarkersforbipolariidisorderarecorrelatedwithaffectivecognitiveperformance AT kuowangtsai proteinbiomarkersforbipolariidisorderarecorrelatedwithaffectivecognitiveperformance |