Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches
JC and BK polyomaviruses were discovered over 40 years ago and have become increasingly prevalent causes of morbidity and mortality in a variety of distinct, immunocompromised patient cohorts. The recent discoveries of eight new members of the Polyomaviridae family that are capable of infecting hum...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/373579 |
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| _version_ | 1832568331345854464 |
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| author | Cillian F. De Gascun Michael J. Carr |
| author_facet | Cillian F. De Gascun Michael J. Carr |
| author_sort | Cillian F. De Gascun |
| collection | DOAJ |
| description | JC and BK polyomaviruses were discovered over 40 years ago and have become increasingly prevalent causes of morbidity and mortality in a variety of distinct, immunocompromised patient cohorts. The recent discoveries of eight new members of the Polyomaviridae family that are capable of infecting humans suggest that there are more to be discovered and raise the possibility that they may play a more significant role in human disease than previously understood. In spite of this, there remains a dearth of specific therapeutic options for human polyomavirus infections and an incomplete understanding of the relationship between the virus and the host immune system. This review summarises the human polyomaviruses with particular emphasis on pathogenesis in those directly implicated in disease aetiology and the therapeutic options available for treatment in the immunocompromised host. |
| format | Article |
| id | doaj-art-fd2f478829134764a4246bbd54229a06 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-fd2f478829134764a4246bbd54229a062025-02-03T00:59:18ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/373579373579Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment ApproachesCillian F. De Gascun0Michael J. Carr1Department of Virology, Frimley Park Hospital, Frimley, Surrey GU16 7UJ, UKNational Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, IrelandJC and BK polyomaviruses were discovered over 40 years ago and have become increasingly prevalent causes of morbidity and mortality in a variety of distinct, immunocompromised patient cohorts. The recent discoveries of eight new members of the Polyomaviridae family that are capable of infecting humans suggest that there are more to be discovered and raise the possibility that they may play a more significant role in human disease than previously understood. In spite of this, there remains a dearth of specific therapeutic options for human polyomavirus infections and an incomplete understanding of the relationship between the virus and the host immune system. This review summarises the human polyomaviruses with particular emphasis on pathogenesis in those directly implicated in disease aetiology and the therapeutic options available for treatment in the immunocompromised host.http://dx.doi.org/10.1155/2013/373579 |
| spellingShingle | Cillian F. De Gascun Michael J. Carr Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches Clinical and Developmental Immunology |
| title | Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches |
| title_full | Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches |
| title_fullStr | Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches |
| title_full_unstemmed | Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches |
| title_short | Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches |
| title_sort | human polyomavirus reactivation disease pathogenesis and treatment approaches |
| url | http://dx.doi.org/10.1155/2013/373579 |
| work_keys_str_mv | AT cillianfdegascun humanpolyomavirusreactivationdiseasepathogenesisandtreatmentapproaches AT michaeljcarr humanpolyomavirusreactivationdiseasepathogenesisandtreatmentapproaches |